Results 11 to 20 of about 58,345 (189)

Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems [PDF]

Cell & Bioscience, 2018
Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an injured heart in Xenopus laevis. Here, we
Souqi Liao, Wenyan Dong, Hui Zhao, Ruijin Huang, Xufeng Qi, Dongqing Cai   +5 more
doaj   +4 more sources

An epigenetic clock for Xenopus tropicalis. [PDF]

NPJ Aging
DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental ...
Bennett R, Morselli M, Petrova K, Peshkin L, Pellegrini M.   +4 more
europepmc   +5 more sources

CRISPR/Cas9-Mediated Models of Retinitis Pigmentosa Reveal Differential Proliferative Response of Müller Cells between Xenopus laevis and Xenopus tropicalis

Cells, 2022
Retinitis pigmentosa is an inherited retinal dystrophy that ultimately leads to blindness due to the progressive degeneration of rod photoreceptors and the subsequent non-cell autonomous death of cones.
Karine Parain, Sophie Lourdel, Alicia Donval, Albert Chesneau, Caroline Borday, Odile Bronchain, Morgane Locker, Muriel Perron   +7 more
doaj   +2 more sources

Modelling human genetic disorders in Xenopus tropicalis [PDF]

Disease Models & Mechanisms
ABSTRACT Recent progress in human disease genetics is leading to rapid advances in understanding pathobiological mechanisms. However, the sheer number of risk-conveying genetic variants being identified demands in vivo model systems that are amenable to functional analyses at scale. Here we provide a practical guide for using the diploid
Helen Rankin Willsey, Eleanor G. Seaby, Annie Godwin, Sarah Ennis, Matthew Guille, Robert M. Grainger   +5 more
doaj   +4 more sources

Comparison of TALEN scaffolds in Xenopus tropicalis [PDF]

Biology Open, 2013
Summary Transcription activator-like effector nucleases (TALENs) are facile and potent tools used to modify a gene of interest for targeted gene knockout.
Keisuke Nakajima, Yoshio Yaoita
doaj   +3 more sources

Cas9-Based Genome Editing in Xenopus tropicalis [PDF]

, 2014
Xenopus tropicalis has been developed as a model organism for developmental biology, providing a system offering both modern genetics and classical embryology.
Nakayama, Takuya, Ira L. Blitz, Blitz, Ira L, Grainger, Robert M, Margaret B. Fish, Akinleye O. Odeleye, Sumanth Manohar, Takuya Nakayama, Fish, Margaret B, Cho, Ken WY, Ken W.Y. Cho, Robert M. Grainger, Odeleye, Akinleye O, Manohar, Sumanth   +13 more
core   +4 more sources

Targeted integration of genes in Xenopus tropicalis

genesis, 2017
With the successful establishment of both targeted gene disruption and integration methods in the true diploid frog Xenopus tropicalis, this excellent vertebrate genetic model now is making a unique contribution to modelling human diseases.
Shi, Zhaoying, Guo, Xiaogang, Xin, Huhu, Chen, Yonglong, Tian, Dandan, Lian, Jingru   +5 more
core   +4 more sources

The methyltransferase activity of Dot1L is essential for Xenopus tropicalis tadpole development and survival [PDF]

Cell & Bioscience
Epigenetic modifications of histones play key roles in transcriptional regulation by diverse transcription factors. One such modification is the methylation of histone H3 at lysine 79 (H3K79).
Emeric M. Louis, Nga Luu, Laurent M. Sachs, Yun-Bo Shi   +3 more
doaj   +2 more sources

Metamorphic gene regulation programs in Xenopus tropicalis tadpole brain [PDF]

PLoS ONE, 2023
Amphibian metamorphosis is controlled by thyroid hormone (TH), which binds TH receptors (TRs) to regulate gene expression programs that underlie morphogenesis.
Samhitha Raj, Christopher J. Sifuentes, Yasuhiro Kyono, Robert J. Denver   +3 more
doaj   +2 more sources

Protocol for tail vein injection in Xenopus tropicalis tadpoles [PDF]

STAR Protocols
Summary: Functional studies in post-embryonic Xenopus tadpoles are challenging because embryonic perturbations often lead to developmental consequences, such as lethality.
Jeet H. Patel, Avery Angell Swearer, Anneke D. Kakebeen, Lauren Rajchel Loh, Andrea E. Wills   +4 more
doaj   +2 more sources