Results 101 to 110 of about 654,596 (326)
Regulation of Cdc42 and its effectors in epithelial morphogenesis
Journal of Cell Science, 2019 Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen ...
F. Pichaud +2 more
semanticscholar +1 more source
Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks
Advanced Functional Materials, EarlyView.Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert +10 more
wiley +1 more source
Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects
eLife, 2020 Cell shape and cell-envelope integrity of bacteria are determined by the peptidoglycan cell wall. In rod-shaped Escherichia coli, two conserved sets of machinery are essential for cell-wall insertion in the cylindrical part of the cell: the Rod complex ...
Antoine Vigouroux +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Visualizing Morphogenesis through Instability Formation in 4-D Printing. [PDF]
, 2019 Heterogeneous growth in a myriad of biological systems can lead to the formation of distinct morphologies during the maturation processes of different species.
Frenkel, Imri +7 more
core
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration
Nature CommunicationsBone regeneration requires a well-orchestrated cellular and molecular response including robust vascularization and recruitment of mesenchymal and osteogenic cells.
M. Gabriele Bixel +10 more
doaj +1 more source
Fluid Forces Control Structural Remodeling of Blind‐Ended Lymphatic Microvessels
Advanced Healthcare Materials, EarlyView.Using innovative microfluidic biofabrication with fluid mechanical insights, we recapitulated the blind‐ended microanatomy and physiological drainage properties of capillary lymphatics. Our results reveal the interrelationship between intra‐ and extraluminal regions of lymphatic vessels due to flow‐induced sprouting and morphological changes that ...
Jacob C. Holter +5 more
wiley +1 more source
Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells
Nature CommunicationsArterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it is appreciated that defective formation or compromised function of arteries is associated with a range of human diseases ...
Esther Bovay +8 more
doaj +1 more source
Simplifying Genotyping of Mutants from Genome Editing with a Parallel qPCR-Based iGenotype Index
CellsTargeted genome editing is a powerful tool in reverse genetic studies of gene function in many aspects of biological and pathological processes. The CRISPR/Cas system or engineered endonucleases such as ZFNs and TALENs are the most widely used genome ...
Liezhen Fu +6 more
doaj +1 more source