Results 91 to 100 of about 459,719 (297)

Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration

Nature Communications
Bone regeneration requires a well-orchestrated cellular and molecular response including robust vascularization and recruitment of mesenchymal and osteogenic cells.
M. Gabriele Bixel, Kishor K. Sivaraj, Melanie Timmen, Vishal Mohanakrishnan, Anusha Aravamudhan, Susanne Adams, Bong-Ihn Koh, Hyun-Woo Jeong, Kai Kruse, Richard Stange, Ralf H. Adams   +10 more
doaj   +1 more source

Epithelial-mesenchymal feedback signalling during vertebrate organogenesis : genetic analysis of BMP-Gremlin1 antagonistic interactions [PDF]

, 2010
Branching morphogenesis of the metanephric kidney relies on an intricate molecular system that controls a highly regulated developmental program. Metanephric kidney organogenesis involves a complex system of epithelial mesenchymal interactions that ...
Gonçalves, Alexandre
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells

Nature Communications
Arterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it is appreciated that defective formation or compromised function of arteries is associated with a range of human diseases ...
Esther Bovay, Kai Kruse, Emma C. Watson, Vishal Mohanakrishnan, Martin Stehling, Frank Berkenfeld, Mara E. Pitulescu, Mark L. Kahn, Ralf H. Adams   +8 more
doaj   +1 more source

Simplifying Genotyping of Mutants from Genome Editing with a Parallel qPCR-Based iGenotype Index

Cells
Targeted genome editing is a powerful tool in reverse genetic studies of gene function in many aspects of biological and pathological processes. The CRISPR/Cas system or engineered endonucleases such as ZFNs and TALENs are the most widely used genome ...
Liezhen Fu, Shouhong Wang, Lusha Liu, Yuki Shibata, Morihiro Okada, Nga Luu, Yun-Bo Shi   +6 more
doaj   +1 more source

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

eLife, 2020
Blood vessels are integrated into different organ environments with distinct properties and physiology (Augustin and Koh, 2017). A striking example of organ-specific specialization is the bone vasculature where certain molecular signals yield the ...
Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams   +8 more
doaj   +1 more source

petal morphogenesis of lisianthus

, 2023
Supplementary figures and data of the article of petal morphogenesis of ...
Yuwei Liang (12880949)
core   +1 more source

Heat‐Suppressing Projection Two‐Photon Lithography Enables High‐Throughput Sub‐Micrometer Manufacturing of Biopolymer Hydrogels for Tissue Engineering

Advanced Science, EarlyView.
The iLEAP technique integrates high‐throughput two‐photon lithography with extrusion printing, bridging sub‐micrometer precision and macroscopic scaffold fabrication. By employing a low‐exothermic photoinitiator, it mitigates thermal damage to biopolymers and preserves bioactivity.
Qifeng Guan, Yanzhe Fu, Xiangyu Xu, Naitao Li, Sen Hou, Kai Wang, Yufan Wang, Jiakun Li, Ping Li, Jiebo Li, Lizhen Wang, Yubo Fan   +11 more
wiley   +1 more source

Endothelial EphB4 maintains vascular integrity and transport function in adult heart

eLife, 2019
The homeostasis of heart and other organs relies on the appropriate provision of nutrients and functional specialization of the local vasculature. Here, we have used mouse genetics, imaging and cell biology approaches to investigate how homeostasis in ...
Guillermo Luxán, Jonas Stewen, Noelia Díaz, Katsuhiro Kato, Sathish K Maney, Anusha Aravamudhan, Frank Berkenfeld, Nina Nagelmann, Hannes CA Drexler, Dagmar Zeuschner, Cornelius Faber, Hermann Schillers, Sven Hermann, John Wiseman, Juan M Vaquerizas, Mara E Pitulescu, Ralf H Adams   +16 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source