Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles. [PDF]
Chemistry, 2023 We report a heterocyclic merging approach to construct novel indazolo-piperazines and indazolo-morpholines. Starting from chiral diamines and amino alcohols, novel regiochemically (1,3 and 1,4) and stereochemically diverse (relative and absolute) cohorts
Viveki AB +6 more
europepmc +2 more sources
Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons [PDF]
Communications Chemistry, 2023 Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj +2 more sources
Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines [PDF]
Pharmacia, 2021 By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used
Yuliia Matiichuk +6 more
doaj +4 more sources
Copper-Catalyzed Three-Component Synthesis of Highly Substituted Morpholines. [PDF]
Org LettUnprotected, highly substituted morpholines were obtained through a copper-catalyzed three-component reaction utilizing amino alcohols, aldehydes, and diazomalonates.
Chu D, Zoll AJ, Ellman JA.
europepmc +2 more sources
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors [PDF]
Molecules, 2017 The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial activities of a new series of 2-(4 ...
Nafiz Öncü Can +7 more
doaj +2 more sources
Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers. [PDF]
ACS Catal, 2022 We report a photocatalyzed epimerization of morpholines and piperazines that proceeds by reversible hydrogen atom transfer (HAT) and provides an efficient strategy for editing the stereochemical configurations of these saturated nitrogen heterocycles ...
Shen Z +4 more
europepmc +2 more sources
Expanding Complex Morpholines Using Systematic Chemical Diversity. [PDF]
Org LettThe morpholine heterocycle is a structural unit found in many bioactive compounds and FDA-approved drugs, but the generation of more complex C-functionalized morpholine derivatives remains considerably underexplored.
Tang SA +9 more
europepmc +2 more sources
Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
Beilstein Journal of Organic Chemistry, 2015 The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type
Hongnan Sun +4 more
doaj +2 more sources
New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2017 Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their ...
Esmail Vessally +4 more
doaj +1 more source
Isostearamidopropyl Morpholine Lactate [PDF]
International Journal of Toxicology, 2017 Monice Fiume
openaire +3 more sources