Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines [PDF]
Pharmacia, 2021 By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used
Yuliia Matiichuk +6 more
doaj +4 more sources
Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons [PDF]
Communications Chemistry, 2023 Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj +2 more sources
Current Research in Toxicology, 2022 The cardiac embryonic stem cell test (ESTc) is a well-studied non-animal alternative test method based on cardiac cell differentiation inhibition as a measure for developmental toxicity of tested chemicals.
R.H. Mennen +5 more
doaj +2 more sources
Copper-Catalyzed Three-Component Synthesis of Highly Substituted Morpholines. [PDF]
Org LettUnprotected, highly substituted morpholines were obtained through a copper-catalyzed three-component reaction utilizing amino alcohols, aldehydes, and diazomalonates.
Chu D, Zoll AJ, Ellman JA.
europepmc +2 more sources
Expanding Complex Morpholines Using Systematic Chemical Diversity. [PDF]
Org LettThe morpholine heterocycle is a structural unit found in many bioactive compounds and FDA-approved drugs, but the generation of more complex C-functionalized morpholine derivatives remains considerably underexplored.
Tang SA +9 more
europepmc +2 more sources
Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
Beilstein Journal of Organic Chemistry, 2015 The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type
Hongnan Sun +4 more
doaj +2 more sources
Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them. [PDF]
Medičnì Perspektivi, 2016 The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous +3 more
doaj +2 more sources
Morpholin-4-ium morpholine-4-carbodithioate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2011 The title compound, C(4)H(10)NO(+)·C(5)H(8)NOS(2) (-), is built up of a morpholinium cation and a dithio-carbamate anion. In the crystal, two structurally independent formula units are linked via N-H⋯S hydrogen bonds, forming an inversion dimer, with graph-set motif R(4) (4)(12).
Ana C. Mafud +2 more
openaire +3 more sources
ACS Catalysis, 2022 We report a photocatalyzed epimerization of morpholines and piperazines that proceeds by reversible hydrogen atom transfer (HAT) and provides an efficient strategy for editing the stereochemical configurations of these saturated nitrogen heterocycles ...
Zican Shen +4 more
semanticscholar +1 more source
Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
Chemical Science, 2021 Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and ...
Ming-Xing Li +5 more
semanticscholar +1 more source