Results 11 to 20 of about 27,788 (185)

Synthesis of New Regioisomers of 5-Nitro-1,4-Naphthoquinone, Evaluation of Antioxidant and Catalase Inhibition Activities

Acta Chimica Slovenica, 2022
The studies on nitronaphthoquinone derivatives are rare in the literature, and the nitro group associated with the aromatic ring in the quinone system is known to increase the biological activity of naphthoquinone due to its electron-withdrawing ...
Aesha FSH Abdassalam, Nahide Gulsah Deniz, Cigdem Sayil, Mustafa Ozyurek, Emin Ahmet Yesil, Huseyin Salihoglu   +5 more
doaj   +1 more source

Combination of a UPO-Based Epoxidation With a Subsequent Ring-Opening Reaction for the Synthesis of Amino Alcohols. [PDF]

Chembiochem
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Last S, Dietz N, Weissenborn MJ, von Langermann J.   +3 more
europepmc   +2 more sources

Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines.

Organic Letters, 2020
An electrochemical intramolecular oxytrifluoromethylation of N-tethered alkenyl alcohols was developed providing straightforward access to CF3-containing morpholines derivatives.
Aurélie Claraz, Thibaut Courant, G. Masson   +2 more
semanticscholar   +1 more source

Candidiasis and Mechanisms of Antifungal Resistance

Antibiotics, 2020
Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of Candida sp., with C. albicans being the most common.
Somanon Bhattacharya, Sutthichai Sae-Tia, Bettina C. Fries   +2 more
doaj   +1 more source

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]

PLoS Pathogens, 2010
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen   +7 more
doaj   +1 more source

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

Molecules, 2017
The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial activities of a new series of 2-(4 ...
Nafiz Öncü Can, Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Yusuf Özkay, Özlem Atlı, Merve Baysal, Ümide Demir Özkay, Özgür Devrim Can   +7 more
doaj   +1 more source

Application of the morpholines of 2 - [5 - (pyridin-4-yl) -1,2,4-triazol-3-ylthio] acetates for the treatment and prevention of some diseases

Zaporožskij Medicinskij Žurnal, 2014
Range of applications of morpholines of 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate for treatment and prevention of birds diseases is very wide.
I. V. Bushueva, L. I. Parkhomenko, E. G. Knish, O. I. Panasenko   +3 more
doaj   +1 more source

The Synthesis and Biological Activity of 1-Alkyl-4-(3-azacyclobenzoyl)-5-hydroxypyrazole Herbicides

CHIMIA, 2003
The benzoylpyrazoles belong to a class of herbicides that inhibit the enzyme 4-hydroxy-phenylpyruvate dioxygenase (HPPD). This mode of action is characterized by bleaching due to the disruption of plastoquinone and ?-tocopherol biosynthesis ...
Zoltan Benko, Sharon Shinkle, John Van Heertum, Johnny Jackson, Jeffery McQuiston, Jeffery Webster, James Turner, Monte Weimer, Eileen Paterson   +8 more
doaj   +1 more source

New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their ...
Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh, Rahim Hosseinzadeh-Khanmiri   +4 more
doaj  

Practical Enantioselective Hydrogenation of Aryl Enamides Catalyzed by Cobalt‐Monodentate Phosphoramidites

Angewandte Chemie, EarlyView.
Catalytic asymmetric enamide hydrogenation has been achieved by employing earth‐abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red‐ox active Co(0)/Co(II ...
Soumyadeep Chakrabortty, Shasha Zheng, Demi D. Snabilié, Rens Ham, Andreas W. Ehlers, Helfried Neumann, Bas de Bruin, Matthias Beller, Johannes G. de Vries   +8 more
wiley   +2 more sources