Results 21 to 30 of about 29,476 (244)

Ultrasonicated Synthesis of N-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation

E-Journal of Chemistry, 2010
A facile five step synthesis of N-benzyl-2,3-substituted morpholines (i-iii) was performed. The key steps were microwave assisted Friedel-crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using DEAD ...
B. Jayachandra Reddy, M. C. Somasekhara Reddy   +1 more
doaj   +1 more source

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

Regulatory Mechanisms in Biosystems, 2018
We carried out MIC of the derivatives of 1,2,4-triazole II (4-((5-nitrofuran-2-yl)methyleneamino)-1-propyl-4H-1,2,4-triazolium bromide) and I (N-((5-nitrofuran-2-yl)methylene)-4H-4-amino-1,2,4-triazolidium chloride) against Escherichia coli ATCC 3912/4 ...
M. S. M. Alrawashdeh
doaj   +1 more source

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

Angewandte Chemie, EarlyView.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh‐Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, Renzo Luisi   +10 more
wiley   +2 more sources

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines.

Organic Letters, 2019
A new methodology to synthesize 2,6-di-, and 2,2',6-trisubstituted morpholines via the reduction of oxabicyclic tetrazoles under mild conditions is described.
E. Duchamp, B. Simard, S. Hanessian
semanticscholar   +1 more source

One-Step Synthesis of Diaza Macrocycles by Rh(II)-Catalyzed [3 + 6 + 3 + 6] Condensations of Morpholines and α-Diazo-β-ketoesters.

Organic Letters, 2019
Selective formation of oxonium ylides from morpholines and α-diazo-β-ketoesters was achieved. This was applied to the high-concentration (0.5 M) dirhodium-catalyzed (0.1 mol %) [3 + 6 + 3 + 6] synthesis of 18-membered ring diaza macrocycles (46%-72 ...
Alexandre Homberg, D. Poggiali, Mahesh Vishe, C. Besnard, L. Guénée, J. Lacour   +5 more
semanticscholar   +1 more source

Synthesis of Functionalized Homoallylic Alcohols via a Salt‐Free Three‐Component Nickel‐Catalyzed Coupling Reaction

Advanced Synthesis &Catalysis, EarlyView.
A nickel catalyzed three‐component coupling reaction between an aldehyde, a secondary amine, and butadiene allows a straightforward access to 5‐aminopent‐3‐en‐1‐ol scaffolds according to a salt‐free process. Key steps are oxidative coupling reaction between one aldehyde, one butadiene on a low valent nickel precursor, and the nucleophilic attack of a ...
Anthony Saint Pol, Maxime Roger, Alexis Mifleur, Pauline Loxq, Laëtitia Chausset‐Boissarie, Aurélien Béthegnies, Maël Penhoat, Isabelle Suisse, Mathieu Sauthier   +8 more
wiley   +1 more source

Beetles “in red”: are the endangered flat bark beetles Cucujus cinnaberinus and C. haematodes chemically protected? (Coleoptera: Cucujidae)

The European Zoological Journal, 2018
Two native species of the genus Cucujus show a wide geographic distribution in Europe, Cucujus cinnaberinus (Scopoli, 1763) and C. haematodes Erichson, 1845.
T. Bonacci, A. Mazzei, A. Naccarato, R. Elliani, A. Tagarelli, P. Brandmayr   +5 more
doaj   +1 more source

Exploring the Uncharted Indolizine Chemical Space: Construction of 5‐Acylindolizines via a Domino Aldol–Vinylogous Aldol Process

Advanced Synthesis &Catalysis, EarlyView.
A domino aldol condensation–intramolecular vinylogous aldol condensation process was implemented for the first time to enable access to a wide range of novel 5‐acylated indolizines with a hydrogen, an alkyl, an aryl, or an alkoxy moiety at the C7 site.
Dohui Ku, Sunhee Lee, Ikyon Kim
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

4-(4-Nitrobenzyl)morpholine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(11)H(14)N(2)O(3), an inter-molecular inter-action between a nitro group O atom and a neighboring benzene ring helps to stabilize the crystal structure [N⋯centroid = 3.933 (2) Å]. No classical hydrogen bonds are observed in the crystal packing.
Ling-Ling Yang, Ren-Lin Zheng, Guo-Bo Li, Qi-Zheng Sun, Yong-Mei Xie   +4 more
openaire   +3 more sources