Results 21 to 30 of about 21,395 (260)

New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their ...
Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh, Rahim Hosseinzadeh-Khanmiri   +4 more
doaj  

Structure Prediction and Functional Characterization of ERG Proteins Involved in Ergosterol Biosynthetic Pathway of Candida albicans [PDF]

, 2011
The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and
Ashok Sharma, Suaib Luqman, Sudeep Roy   +2 more
core   +2 more sources

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Beilstein Journal of Organic Chemistry, 2015
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type
Hongnan Sun, Binbin Huang, Run Lin, Chao Yang, Wujiong Xia   +4 more
doaj   +1 more source

Cupin‐Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKPu) Catalyzes Aza‐Michael Addition of Primary and Secondary Amines to Acrylic Acid

Angewandte Chemie, EarlyView.
A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri, Angela Mourelle, Teodor Parella, Jordi Bujons, Carlos J. Moreno, Pere Clapés   +5 more
wiley   +2 more sources

Ultrasonicated Synthesis of N-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation

E-Journal of Chemistry, 2010
A facile five step synthesis of N-benzyl-2,3-substituted morpholines (i-iii) was performed. The key steps were microwave assisted Friedel-crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using DEAD ...
B. Jayachandra Reddy, M. C. Somasekhara Reddy   +1 more
doaj   +1 more source

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

Regulatory Mechanisms in Biosystems, 2018
We carried out MIC of the derivatives of 1,2,4-triazole II (4-((5-nitrofuran-2-yl)methyleneamino)-1-propyl-4H-1,2,4-triazolium bromide) and I (N-((5-nitrofuran-2-yl)methylene)-4H-4-amino-1,2,4-triazolidium chloride) against Escherichia coli ATCC 3912/4 ...
M. S. M. Alrawashdeh
doaj   +1 more source

4-(4-Nitrobenzyl)morpholine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(11)H(14)N(2)O(3), an inter-molecular inter-action between a nitro group O atom and a neighboring benzene ring helps to stabilize the crystal structure [N⋯centroid = 3.933 (2) Å]. No classical hydrogen bonds are observed in the crystal packing.
Qi-Zheng Sun, Yongmei Xie, Guo-Bo Li, Ren-Lin Zheng, Yang Lingling   +4 more
openaire   +4 more sources

Dirhodium-catalyzed C-H arene amination using hydroxylamines [PDF]

, 2016
Primary and N-alkyl arylamine motifs are key functional groups in pharmaceuticals, agrochemicals, and functional materials, as well as in bioactive natural products. However, there is a dearth of generally applicable methods for the direct replacement of
Adebesin, Adeniyi Michael, Burt, Scott R., Ess, Daniel H., Falck, John R., Kürti, László, Ma, Zhiwei, Paudyal, Mahesh P.   +6 more
core   +1 more source

Widespread contamination of wildflower and bee-collected pollen with complex mixtures of neonicotinoids and fungicides commonly applied to crops [PDF]

, 2016
There is considerable and ongoing debate as to the harm inflicted on bees by exposure to agricultural pesticides. In part, the lack of consensus reflects a shortage of information on field-realistic levels of exposure. Here, we quantify concentrations of
Artz, Beekman, Bingham, Bonmatin, Botías, Carreck, Cresswell, Cresswell, David, Demske, du Rand, Dussaubat, Fairbrother, Goulson, Goulson, Goulson, Gupta, Heinrich, Human, Iwasa, Johnson, Johnson, Khan, Kirk, Knight, Lambert, Moore, Mullin, Mullin, Osborne, Rundlöf, Sanchez-Bayo, Sawyer, Schmuck, Suchail, Thompson, Whitehorn, Wood, Yoder, Yoder, Zhu   +40 more
core   +1 more source

(Morpholin-4-yl)[2-(morpholin-4-yl)-3,5-dinitrophenyl]methanone [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(15)H(18)N(4)O(7), the morpholine rings adopt chair conformations. The benzene ring forms dihedral angles of 55.94 (7) and 63.19 (7)° with the planes through the C atoms of the two morpholine rings.
Luoting Yu, Chao Gao, Yong Xia, Ying Xiong   +3 more
openaire   +4 more sources