Results 31 to 40 of about 21,395 (260)
Angewandte Chemie, EarlyView.Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij +8 more
wiley +2 more sources
Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates [PDF]
, 2013 The present study was conducted to synthesize nitrogen containing derivatives of salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats.
Ali, Gowhar +6 more
core +1 more source
Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
Angewandte Chemie, EarlyView.DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence‐specifically label protein‐coding RNAs, or to knock down expression selectively, with potential applications in basic transcriptome research and in future ...
Sumon Pratihar +4 more
wiley +2 more sources
4-(4-Nitrophenyl)morpholine [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 Aromatic π–π stacking interactions stabilize the crystal structure of the title compound, C10H12N2O3, the perpendicular distance between parallel planes being 3.7721 (8) Å. The morpholine ring adopts a chair comformation.
Wei-Wei Li +3 more
openaire +4 more sources
Angewandte Chemie, EarlyView.A readily accessible, well‐defined iron(II) catalyst that demonstrates high efficiency and versatility in positional and geometrical alkene isomerization is presented. A comprehensive mechanistic study suggests an alkyl mechanism via an isolable iron hydride species and indicates the stereo‐ and rate‐determining β‐hydride elimination step exhibits a ...
Abdul‐Halim Obeid +3 more
wiley +2 more sources
On‐Target Photoassembly of Pyronin Dyes for Super‐Resolution Microscopy
Angewandte Chemie, EarlyView.We report a new class of diaryl ether and diaryl silane compounds bearing hydrazone substituents that, upon irradiation, cyclize to a fluorescent (silicon−)pyronin dye. After optimizing their photophysical properties, we introduced reactive tags into their structure for biological labeling, and demonstrated their utility in STED, PALM, and MINFLUX ...
Gergely Knorr +2 more
wiley +2 more sources
Amine-Promoted Alkene Aziridination
, 2011 Aziridines, the smallest saturated aza-heterocycle, are not only prevalent in several natural products, but also represent a versatile synthetic tool for the chemist via exploitation of the strained ring system. Research described in this thesis concerns
Pullin, Robert David Charles +1 more
core +1 more source
Morpholine-4-carboxamidinium sulfate [PDF]
IUCrData, 2016 The asymmetric unit of the title salt, 2C5H12N3O+·SO42−, comprises two cations and one sulfate ion. In both cations, the C, N and O atoms of the morpholine rings are disordered over two sets of sites, with refined occupancies of 0.849 (3):0.151 (3) for cation I and 0.684 (4):0.316 (4) for cation II. The C—N bond lengths in both central C3N units of the
Willi Kantlehner, Ioannis Tiritiris
openaire +2 more sources
Advanced Materials, EarlyView.This review describes recent developments in the design and synthesis of metal–organic frameworks (MOF)/textile composites for the detoxification of chemical warfare agent and simulants with extensive discussion on the advantages and disadvantages of different methods.
Zhihua Cheng +4 more
wiley +1 more source
The European Zoological Journal, 2018 Two native species of the genus Cucujus show a wide geographic distribution in Europe, Cucujus cinnaberinus (Scopoli, 1763) and C. haematodes Erichson, 1845.
T. Bonacci +5 more
doaj +1 more source