Results 91 to 100 of about 4,012,050 (346)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Hydrological Interpretation of Basin Morphology [PDF]
, 1978 Completion Report OWRT Agreement No. 14-31-0001-5002 OWRT Project A-049-ALASHydrologic processes in a particular basin are governed by three groups of factors: input regimes of mass and energy, the nature of mass and energy transfer and ...
Fox, John D.
core
Galaxy Morphology - Halo Gas Connections
, 2005 We studied a sample of 38 intermediate redshift MgII absorption-selected galaxies using (1) Keck/HIRES and VLT/UVES quasar spectra to measure the halo gas kinematics from MgII absorption profiles and (2) HST/WFPC-2 images to study the absorbing galaxy ...
B. Ménard +5 more
core +2 more sources
Genes and tooth development: reviewing the structure and function of some key players.
Brazilian Journal of Oral Sciences, 2015 Similar to many other embryonic organs, the mammalian tooth development relies largely on epithelial-mesenchymal interactions. Tooth development may be divided in multiple stages, where the number, size and type of teeth are sequentially determined ...
Raquel Mantuaneli S. Caminaga +3 more
doaj +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Block co-polyMOFs: morphology control of polymer-MOF hybrid materials. [PDF]
, 2019 The hybridization of block copolymers and metal-organic frameworks (MOFs) to create novel materials (block co-polyMOFs, BCPMOFs) with controlled morphologies is reported. In this study, block copolymers containing poly(1,4-benzenedicarboxylic acid, H2bdc)
Ayala, Sergio +2 more
core +1 more source
Anatomy and arterial vascularization of female genital system of margay (Leopardus weidii)
Jornal Interdisciplinar de Biociências, 2016 The margay (Leopardus wiedii) belongs to Carnivora order and present’s nocturnal habits. There are few studies using this specie, whereas it is between feline species vulnerable to extinction.
Andrezza Braga Soares Silva +7 more
doaj
, 2013 Galaxy morphology is a product of how galaxies formed, how they interacted with their environment, how they were influenced by internal perturbations, AGN, and dark matter, and of their varied star formation histories. This article reviews the phenomenology of galaxy morphology and classification with a view to delineating as many types as possible and
openaire +4 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source