Results 71 to 80 of about 4,237,150 (301)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Morphology and Properties of Zn-Al-TiO2 Composite on Mild Steel [PDF]

open access: yes, 2012
The influence of TiO2 composite and dispersed pure Al particle on zinc alloy electrodeposited on mild steel was studied from chloride bath solution.Microstructural and mechanical properties of the alloy were investigated.
Fayomi, O. S. I   +3 more
core  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Potentiating Effect of Nitric Oxide Donor on Antitumor Activity of Doxorubicin in Glioblastoma-Bearing Rats

open access: yesАнтибиотики и Химиотерапия, 2020
The objective of the study was to investigate the influence of the NO donor nitroglycerin (NG) on the antitumour effect of doxorubicin (Dox) in rats with the intracranially implanted 101.8 glioblastoma. Materials and methods.
A. I. Alekseeva   +4 more
doaj  

miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment

open access: yesCells, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Ilaria Conti   +6 more
doaj   +1 more source

Hydrological Interpretation of Basin Morphology [PDF]

open access: yes, 1978
Completion Report OWRT Agreement No. 14-31-0001-5002 OWRT Project A-049-ALASHydrologic processes in a particular basin are governed by three groups of factors: input regimes of mass and energy, the nature of mass and energy transfer and ...
Fox, John D.
core  

Skyrmion morphology in ultrathin magnetic films

open access: yes, 2017
Nitrogen-vacancy magnetic microscopy is employed in quenching mode as a non-invasive, high resolution tool to investigate the morphology of isolated skyrmions in ultrathin magnetic films.
Akhtar, W.   +10 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Functional morphology of cephalopod gills [PDF]

open access: yes, 1987
There is a wealth of literature dealing with fish gills (Review, see Hoar & Randall, 1984), yet hardly anything is known about the gills of cephalopods. This is rather surprising considering the commercial importance of the cephalopods.
Eno, Nancy Clare
core  

Home - About - Disclaimer - Privacy