Results 81 to 90 of about 4,215,669 (358)

3D printed spermathecae as experimental models to understand sperm dynamics in leaf beetles

BMC Zoology, 2020
Background Postcopulatory mate choice occurs ubiquitously in the animal kingdom. However, it is usually a major challenge to visualise the process taking place in a body. This fact makes it difficult to understand the mechanisms of the process.
Yoko Matsumura, Sinje Gürke, Halvor T. Tramsen, Stanislav N. Gorb   +3 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

Scientific Reports, 2017
Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi   +5 more
doaj   +1 more source

Genes and tooth development: reviewing the structure and function of some key players.

Brazilian Journal of Oral Sciences, 2015
Similar to many other embryonic organs, the mammalian tooth development relies largely on epithelial-mesenchymal interactions. Tooth development may be divided in multiple stages, where the number, size and type of teeth are sequentially determined ...
Raquel Mantuaneli S. Caminaga, Silvana Pasetto, E. Ribeiro da Silva, Regina Célia Rocha Peres   +3 more
doaj   +1 more source

The filamentous fungal pellet—relationship between morphology and productivity

Applied Microbiology and Biotechnology, 2018
Filamentous fungi are used for the production of a multitude of highly relevant biotechnological products like citric acid and penicillin. In submerged culture, fungi can either grow in dispersed form or as spherical pellets consisting of aggregated ...
Lukas Veiter, Vignesh Rajamanickam, C. Herwig   +2 more
semanticscholar   +1 more source

Affixation in Morphology

, 2020
Affixation is the morphological process that consists of adding an affix (i.e., a bound morpheme) to a morphological base. It is cross-linguistically the most common process that human languages use to derive new lexemes (derivational affixation) or to adapt a word’s form to its morphosyntactic context (inflectional affixation ...
openaire   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Prospects for the use of sialylated immunoglobulins in the treatment of different diseases

Фундаментальная и клиническая медицина, 2020
The central role of glycosylation has been well confirmed in numerous studies. In particular, a change in the glycosylation profile of antibodies is observed in infectious diseases, autoimmune disorders and cancer.
Yu. V. Markina, A. M. Markin, I. A. Sobenin, A. N. Orekhov   +3 more
doaj   +1 more source

Galaxy Morphology

, 2013
Galaxy morphology is a product of how galaxies formed, how they interacted with their environment, how they were influenced by internal perturbations, AGN, and dark matter, and of their varied star formation histories. This article reviews the phenomenology of galaxy morphology and classification with a view to delineating as many types as possible and
openaire   +4 more sources