Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis
Scientific Reports, 2017 Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi +5 more
doaj +1 more source
3D printed spermathecae as experimental models to understand sperm dynamics in leaf beetles
BMC Zoology, 2020 Background Postcopulatory mate choice occurs ubiquitously in the animal kingdom. However, it is usually a major challenge to visualise the process taking place in a body. This fact makes it difficult to understand the mechanisms of the process.
Yoko Matsumura +3 more
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
The Angiogenic Potential of DPSCs and SCAPs in an In Vivo Model of Dental Pulp Regeneration
Stem Cells International, 2017 Adequate vascularization, a restricting factor for the survival of engineered tissues, is often promoted by the addition of stem cells or the appropriate angiogenic growth factors.
Petra Hilkens +5 more
doaj +1 more source
Genes and tooth development: reviewing the structure and function of some key players.
Brazilian Journal of Oral Sciences, 2015 Similar to many other embryonic organs, the mammalian tooth development relies largely on epithelial-mesenchymal interactions. Tooth development may be divided in multiple stages, where the number, size and type of teeth are sequentially determined ...
Raquel Mantuaneli S. Caminaga +3 more
doaj +1 more source
The Effects of Learning in Morphologically Evolving Robot Systems [PDF]
, 2022 Jie Luo +4 more
openalex +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Wetting of crossed fibers: multiple steady states and symmetry breaking
, 2014 We investigate the wetting properties of the simplest element of an array of random fibers: two rigid fibers crossing with an inclination angle and in contact with a droplet of a perfectly wetting liquid.
Bick, Alison D. +3 more
core +3 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source