Results 91 to 100 of about 110,803 (293)

Forecasting Method for Grouped Time Series with the Use of k-Means Algorithm

open access: yes, 2015
The paper is focused on the forecasting method for time series groups with the use of algorithms for cluster analysis. $K$-means algorithm is suggested to be a basic one for clustering.
Astakhova, N. N.   +2 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Coherent forecasts of mortality with compositional data analysis

open access: yesDemographic Research, 2017
Background: Mortality trends for subpopulations, e.g., countries in a region or provinces in a country, tend to change similarly over time. However, when forecasting subpopulations independently, the forecast mortality trends often diverge.
Marie-Pier Bergeron-Boucher   +3 more
doaj   +1 more source

A Practitioner-Oriented Evaluation of Mortality Forecasting Methods: The Case of Australia

open access: yesComparative Population Studies
Practitioners seeking a suitable mortality model for forecasting population by age and sex are presented with many possible choices from the large and growing academic literature on mortality forecasting.
Irina Grossman, Tom Wilson
doaj   +1 more source

Mortality neural forecasting

open access: yes, 2021
Predicting mortality is a major challenge for both demographers and actuaries. The latter need to anticipate various future mortality scenarios with the greatest possible accuracy, as in the case of annuities pricing and longevity risk assessments. However, the current wide range of stochastic mortality models highlights some deficiencies in predicting
openaire   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Evaluation of the Kou-Modified Lee-Carter Model in Mortality Forecasting: Evidence from French Male Mortality Data

open access: yesRisks, 2018
Mortality forecasting has always been a target of study by academics and practitioners. Since the introduction and rising significance of securitization of risk in mortality and longevity, more in-depth studies regarding mortality have been carried out ...
Marie Angèle Cathleen Alijean   +1 more
doaj   +1 more source

FORECASTING MORTALITY: SOME RECENT DEVELOPMENTS

open access: yesProceedings of the 33rd International Academic Conference, Vienna, 2017
Forecasting mortality has been a vital issue in demography and actuarial science. It also has profound implications for pension plan and long-term economic forecasts of the nation. In the present paper we examine various forecasting methods for mortality in the framework of cointegrated time series analysis. The Lee-Carter (LC) method has been regarded
Taku Yamamoto, Hiroaki Chigira
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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