Results 71 to 80 of about 32,817 (302)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Forecasting age-specific breast cancer mortality using functional data models [PDF]
Accurate estimates of future age-specific incidence and mortality are critical for allocation of resources to breast cancer control programs and evaluation of screening programs.
Rob J. Hyndman +2 more
core
Evaluation of simple methods for regional mortality forecasts
Genus, 2018 Background In recent decades, considerable research effort has been dedicated to improving mortality forecasting methods. While making valuable contributions to the literature, the bulk of this research has focused on national populations—yet much ...
Tom Wilson
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A new method to estimate mortality in crisis-affected and resource-poor settings: validation study. [PDF]
, 2010 BACKGROUND: Data on mortality rates are crucial to guide health interventions in crisis-affected and resource-poor settings. The methods currently available to collect mortality data in such settings feature important methodological limitations.
Francesco Checchi +19 more
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
The impact of the choice of life table statistics when forecasting mortality
Demographic Research, 2019 Background: Different ways to forecast mortality have been suggested, with many forecasting models based on the extrapolation of age-specific death rates.
Marie-Pier Bergeron-Boucher +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Forecasting Mortality Rate Using a Neural Network with Fuzzy Inference System [PDF]
Various methods have been developed to improve mortality forecasts. The authors proposed a neuro-fuzzy model to forecast the mortality. The forecasting of mortality is curried out by an ANFIS model which uses a first order Sugeno-type FIS.
Camelia Ioana Ucenic +4 more
core
A Practitioner-Oriented Evaluation of Mortality Forecasting Methods: The Case of Australia
Comparative Population StudiesPractitioners seeking a suitable mortality model for forecasting population by age and sex are presented with many possible choices from the large and growing academic literature on mortality forecasting.
Irina Grossman, Tom Wilson
doaj +1 more source