Results 51 to 60 of about 32,817 (302)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Diabetes burden attributable to air pollution from 1990~2021 and the future trends: a population-based study

Frontiers in Endocrinology
BackgroundThis investigation explores the worldwide impact of diabetes burden associated with air pollution, drawing on data from the Global Burden of Disease Study 2021.MethodThe influence of air pollution on diabetes burden was analyzed at global ...
Qingsong Mao, Xiaoyi Zhu, Xinyi Zhang, Yuzhe Kong   +3 more
doaj   +1 more source

Coherent Mortality Forecasting for Less Developed Countries

Risks, 2021
This paper proposes a coherent multi-population approach to mortality forecasting for less developed countries. The majority of these countries have witnessed faster mortality declines among the young and the working age populations during the past few ...
Hong Li, Yang Lu, Pintao Lyu
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Coherent Mortality Forecasting for the Algerian Population

, 2021
Mortality forecasting is much needed for population projections and actuarial calculations. Forecasting mortality of males and females in an independent way leads in most of cases to some incoherence regarding the expected male-female mortality evolution.
Flici, Farid, Farid Flici
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Global burden of cardiovascular diseases attributable to diet low in vegetables from 1990 to 2021 and forecasting the future trends: a population-based study

Frontiers in Cardiovascular Medicine
BackgroundThis investigation examines the worldwide impact of cardiovascular diseases (CVD) resulting from inadequate vegetable consumption, based on the 2021 Global Burden of Disease Study data.MethodThe study assessed the global, regional, and national
Qingsong Mao, Yuzhe Kong
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Analysis of chronic kidney disease epidemiology in Kazakhstan using nationwide data for 2014–2020 and forecasting future trends of prevalence and mortality for 2030

Renal Failure
According to the Global Burden of Disease (GBD) study, chronic kidney disease (CKD) was prevalent in 697.5 million individuals worldwide in 2017. By 2040, it is anticipated that CKD will rank as the fifth most common cause of death.
Gulnur Zhakhina, Kamilla Mussina, Sauran Yerdessov, Arnur Gusmanov, Yesbolat Sakko, Valdemir Kim, Dmitriy Syssoyev, Meruyert Madikenova, Ainur Assan, Zhanat Kuanshaliyeva, Duman Turebekov, Kuanysh Yergaliyev, Bolat Bekishev, Abduzhappar Gaipov   +13 more
doaj   +1 more source

Forecasting Mortality Rate by Singular Spectrum Analysis

Revstat Statistical Journal, 2015
Singular spectrum analysis (SSA) is a relatively new and powerful non-parametric time series analysis technique that has demonstrated its capability in forecasting different time series in various disciplines.
Rahim Mahmoudvand , Fatemeh Alehosseini , Paulo Canas Rodrigues   +2 more
doaj   +1 more source