Results 41 to 50 of about 32,817 (302)

Two-Population Mortality Forecasting: An Approach Based on Model Averaging

Risks
The analysis of residual life expectancy evolution at retirement age holds great importance for life insurers and pension schemes. Over the last 30 years, numerous models for forecasting mortality have been introduced, and those that allow us to predict ...
Luca De Mori, Pietro Millossovich, Rui Zhu, Steven Haberman   +3 more
doaj   +1 more source

Modelos predictivos de la epidemia de COVID-19 en España con curvas de Gompertz

Gaceta Sanitaria, 2021
Resumen: Durante la crisis de salud internacional provocada por la pandemia de COVID-19, además de conocer los datos sobre contagios, muertes y ocupación de camas hospitalarias también es necesario hacer predicciones que ayuden a la gestión de la crisis ...
Pablo Sánchez-Villegas, Antonio Daponte Codina   +1 more
doaj   +1 more source

Bayesian mortality forecasting with overdispersion [PDF]

Insurance: Mathematics and Economics, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wong, Jackie S.T., Forster, Jonathan J., Smith, Peter W.F.   +2 more
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Lee-Carter mortality forecasting: a multi-country comparison of variants and extensions

Demographic Research, 2006
We compare the short- to medium-term accuracy of five variants or extensions of the Lee-Carter method for mortality forecasting. These include the original Lee-Carter, the Lee-Miller and Booth-Maindonald-Smith variants, and the more flexible Hyndman ...
Leonie Tickle, Rob J. Hyndman, Piet de Jong, Heather Booth   +3 more
doaj  

Improving mortality forecasting using a hybrid of Lee–Carter and stacking ensemble model

Bulletin of the National Research Centre, 2023
Background Mortality forecasting is a critical component in various fields, including public health, insurance, and pension planning, where accurate predictions are essential for informed decision-making.
Samuel Asante Gyamerah, Aaron Akyea Mensah, Clement Asare, Nelson Dzupire   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Affine Mortality Models with Jumps: Parameter Estimation and Forecasting

, 2022
In this paper, we investigate the dynamics of age-cohort survival curves under the assumption that the instantaneous mortality intensity is driven by an affine jump-diffusion (AJD) process. Advantages of an AJD specification of mortality dynamics include
Garces, Len Patrick ; https://orcid.org/, Ungolo, Francesco ; https://orcid.org/, Kolar, Jovana, Sherris, Michael ; https://orcid.org/   +3 more
core  

Lee-Carter mortality forecasting: a multi-country comparison of variants and extensions [PDF]

We compare the short- to medium-term accuracy of five variants or extensions of the Lee-Carter method for mortality forecasting. These include the original Lee-Carter, the Lee-Miller and Booth-Maindonald-Smith variants, and the more flexible Hyndman ...
Heather Booth, Rob Hyndman, Leonie Tickle, Piet de Jong   +3 more
core   +2 more sources