Results 41 to 50 of about 110,803 (293)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Coherent modeling of mortality patterns for age-specific subgroups [PDF]
, 2019 The recent actuarial literature has shown that mortality patterns and trajectories in closely related populations are similar in some respects and that small differences are unlikely to increase in the long run.
Giordano, G. +2 more
core +1 more source
Improving mortality forecasting using a hybrid of Lee–Carter and stacking ensemble model
Bulletin of the National Research Centre, 2023 Background Mortality forecasting is a critical component in various fields, including public health, insurance, and pension planning, where accurate predictions are essential for informed decision-making.
Samuel Asante Gyamerah +3 more
doaj +1 more source
Bayesian mortality forecasting with overdispersion [PDF]
Insurance: Mathematics and Economics, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wong, Jackie S.T. +2 more
openaire +4 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Lee-Carter mortality forecasting: a multi-country comparison of variants and extensions
Demographic Research, 2006 We compare the short- to medium-term accuracy of five variants or extensions of the Lee-Carter method for mortality forecasting. These include the original Lee-Carter, the Lee-Miller and Booth-Maindonald-Smith variants, and the more flexible Hyndman ...
Leonie Tickle +3 more
doaj
Coherent Mortality Forecasting for Less Developed Countries
Risks, 2021 This paper proposes a coherent multi-population approach to mortality forecasting for less developed countries. The majority of these countries have witnessed faster mortality declines among the young and the working age populations during the past few ...
Hong Li, Yang Lu, Pintao Lyu
doaj +1 more source
Dynamic forecasting model for short series age-specific mortality / Wan Zakiyatussariroh Wan Husin [PDF]
, 2017 This thesis presents results of a research in developing a model to forecast mortality using a combination of existing demographic and time series models, specifically proposing a common factor model for forecasting Malaysia mortality using the ...
Wan Husin, Wan Zakiyatussariroh
core
The mortality of the Italian population: Smoothing techniques on the Lee--Carter model
, 2011 Several approaches have been developed for forecasting mortality using the stochastic model. In particular, the Lee-Carter model has become widely used and there have been various extensions and modifications proposed to attain a broader interpretation ...
D'Amato, Valeria +2 more
core +1 more source