Results 61 to 70 of about 366,903 (304)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander, A Hardisty, B Cho, B Collen, B-E Sæther, BJ McGill, C Mora, C Ward-Paige, CA Deutsch, CB Field, CD Thomas, CEL Ferreira, CH Sekercioglu, CM Duarte, CR McClain, D Griffiths, D Policansky, D Post, D Yates, Derek P. Tittensor, DG Jenkins, Drew W. Purves, DW Purves, E Jeppesen, E Macpherson, E Odum, E Siemann, EA Fulton, FS Chapin, G Krinner, GA Kaufman, GM Mace, H Cyr, H Stibor, HR Peinetti, J Cebrian, J Chase, J Gasol, J Merilä, JA Carton, JE Cohen, JH Brown, JL Frangi, JM Sunday, Jon Hutton, JP Rodríguez, JS Millar, Jörn P. W. Scharlemann, K Rose, KA Nagy, KA Schubert, KE Jones, KR Buck, L Tremblay-Boyer, LLM Fedigan, LW Oring, M Behrenfeld, M González-Suárez, Matthew J. Smith, MBJ Harfoot, ME Power, Michael B. J. Harfoot, Michel Loreau, MJ Coe, MJ Morgan, MJ Smith, MJ Vander Zanden, MK Litvak, MR Evans, MW McCoy, N Blakley, N Loeuille, NG Hairston, O Krüger, P Abrams, P Del Giorgio, PK Holland, R Alkemade, R Bustamante, R Gentile, R Meek, R Shine, R Shine, RE Ricklefs, RE Ricklefs, RJ Williams, RJ Williams, RW Sheldon, RW Wilson, S Díaz, S Fretwell, S Jain, S Jennings, S Jennings, S Meiri, S Sitch, SA Sandin, SD Pletcher, Stephen Emmott, T Newbold, T Sousa, Tim Newbold, TJ Case, TJ Webb, U Brose, V Christensen, Vassily Lyutsarev, W Sprules, X Irigoien, Y-J Shin   +109 more
core   +4 more sources

Measures and Models of Mortality

, 2018
Mortality analysis and modeling remains one of the core jobs of demographers, epidemiologists, actuaries, biostatisticians, and other population- studies experts. In this chapter we make a detailed overview of the latest developments in demographic measures and mortality modeling.
Vladimir Canudas-Romo, Stefano Mazzuco, Lucia Zanotto   +2 more
openaire   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Joint modelling of longitudinal and time-to-event data: an illustration using CD4 count and mortality in a cohort of patients initiated on antiretroviral therapy

BMC Infectious Diseases, 2020
Background Modelling of longitudinal biomarkers and time-to-event data are important to monitor disease progression. However, these two variables are traditionally analyzed separately or time-varying Cox models are used.
Nobuhle N. Mchunu, Henry G. Mwambi, Tarylee Reddy, Nonhlanhla Yende-Zuma, Kogieleum Naidoo   +4 more
doaj   +1 more source

Comparing Antonovsky's sense of coherence scale across three UK post-industrial cities [PDF]

, 2014
Objectives: High levels of ‘excess’ mortality (ie, that seemingly not explained by deprivation) have been shown for Scotland compared to England and Wales and, especially, for its largest city, Glasgow, compared to the similarly deprived English cities ...
Buchanan, Duncan, Jones, Russell, McCartney, Gerry, McCullough, Sarah, Walsh, David   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Parametric Factor Model of the Term Structure of Mortality

Econometrics, 2019
The prototypical Lee–Carter mortality model is characterized by a single common time factor that loads differently across age groups. In this paper, we propose a parametric factor model for the term structure of mortality where multiple factors are
Niels Haldrup, Carsten P. T. Rosenskjold   +1 more
doaj   +1 more source

Estimating exposure response functions using ambient pollution concentrations [PDF]

, 2007
This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution.
Lee, Duncan, Salway, Ruth, Salway, Ruth, Shaddick, Gavin, Zidek, James V.   +4 more
core   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source