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A RETROSPECTIVE STUDY ON NEUROPSYCHOLOGICAL AND AUTONOMIC OBSERVATIONS OF CASPR2-RELATED MORVAN SYNDROME. [PDF]

Introduction: The defining feature of Morvan syndrome is cerebral, autonomic, and peripheral hyperexcitability; this is caused by the antibody against contactin-associated protein 2 (CASPR2).
Singh, Rashmi, Kumar, Nikhil
core   +1 more source

Flore vasculaire indicatrice des forêts anciennes du Morvan

, 2021
Les forêts anciennes sont reconnues comme présentant des caractéristiques environnementales favorables à une biodiversité spécifique par rapport aux forêts récentes.
Vallet, Jeanne, Nicod, Corentin
core   +3 more sources

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Frontiers in Cellular Neuroscience, 2015
Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion molecule that clusters voltage-gated potassium channels (Kv1.1/1.2) at the juxtaparanodes of myelinated axons and may regulate axonal excitability.
Delphine ePinatel, Bruno eHivert, José eBoucraut, Margaux eSaint-Martin, Margaux eSaint-Martin, Margaux eSaint-Martin, Veronique eRogemond, Veronique eRogemond, Veronique eRogemond, Lida eZoupi, Domna eKaragogeos, Jerome eHonnorat, Jerome eHonnorat, Jerome eHonnorat, Catherine eFaivre-Sarrailh   +14 more
doaj   +1 more source

Teclistamab in Elderly Patients With Relapsed/Refractory Multiple Myeloma: A Subgroup Analysis of the French RetrosTECtive Cohort

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Introduction Real‐world data on teclistamab in relapsed or refractory multiple myeloma (R/R MM), particularly in elderly patients, remain limited. Methods We analysed efficacy and safety outcomes in patients ≥ 75 years from the French RetrosTECtive cohort.
A. Coste, S. Godet, S. Manier, J. R. Eveillard, C. Croizier, C. Mariette, C. Breal, H. Manjra, C. Touzeau, M. Mohty, R. Belkhir, A. Bobin, A. Lévêque, B. Cherel, L. Montes, F. Orsini‐Piocelle, L. Frenzel, D. Robu, E. Chalayer, S. Harel, L. Vincent, L. Bauschert, A. Dony, R. Tabrizi, P. Moreau, C. Hulin, A. Perrot   +26 more
wiley   +1 more source

CASPR2 Autoimmune Antibodies Induce Neuronal Hyperactivity in Human Brain Organoids

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Maternal antibodies targeting CASPR2 are a known risk factor for neurodevelopmental disorders, yet their impact on early human brain development remains unclear. We modeled this exposure using human neural organoids treated with patient‐derived CASPR2 antibodies up to the age of 6 months.
Ana Rafaela Oliveira, Giuseppe Cammarata, Catarina Seabra, Ana Maria Cardoso, Henrique J. Santos, Joana Guedes, Diana Sequeira, João Miguel Marques Santos, Guiomar Oliveira, Ana Luísa Cardoso, Dominique Fernandes, Maria Isabel Leite, Ester Coutinho, Ana Luísa Carvalho, Lino Ferreira, João Peça   +15 more
wiley   +1 more source

Scientific Evidence and Common Perceptions of Factors Affecting Sugar Content in Pasture Grass: Is There a Link With Pre‐existing Horse‐Related Experience?

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
ABSTRACT Background Several equine conditions are associated with and exacerbated by increased high‐sugar grass intake. Knowing how climatic and biotic factors affect sugar content in grasses is important for decision‐making by those involved in the management of equines.
Isabel Moaby, Alex Aitken, Sandra Varga
wiley   +1 more source

Clinical characteristics of peripheral nerve hyperexcitability syndrome

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To summarize the clinical characteristics of peripheral nerve hyperexcitability syndrome (PNHS). Methods and Results Ten patients with PNHS were admitted to He'nan Provincial People's Hospital from October 2018 to April 2022, with the clinical ...
MEI Wen-li, LI Liu-yi, FENG Shu-yan, ZHANG Jie-wen   +3 more
doaj   +1 more source

Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group

Andrology, Volume 14, Issue 1, Page 10-24, January 2026.
ABSTRACT Background Numerous publications have questioned the lack of analytical reliability and clinical relevance of sperm morphology assessment for infertility workup and before use of assisted reproductive techniques (ART). There is a huge variability in the performance and interpretation of this test.
Nicolas Gatimel, Anne‐Laure Barbotin, Lionel Mery, Damien Beauvillard, Marion Bendayan, Angèle Boursier, Thomas Boueilh, Bruno Pereira, Jérémy Chammas, Jean‐Claude Jacquet, Rachel Levy, Jérôme Pfeffer, Hanae Pons‐Rejraji, Pierre Sanguinet, Florence Brugnon   +14 more
wiley   +1 more source

Morvan’s syndrome treated successfully with rituximab and lacosamide

BMJ Case Reports, 2019
We describe a woman with both central and peripheral nervous system symptoms consistent with Morvan’s syndrome who was successfully treated with immunosuppression including rituximab and the new antiepileptic drug lacosamide against peripheral nerve hyperexcitability.
Olafur, Sveinsson, Faiez, Al Nimer, Fredrik, Piehl   +2 more
openaire   +3 more sources

Paraneoplastic Motor Neuropathy in Nodular Sclerosis Hodgkin’s Lymphoma: Case Report

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Paraneoplastic neurological syndromes (PNS) are an uncommon complication of malignancy, characterized by autoantibody generation against neuronal structures, causing a spectrum of neurological syndromes affecting the central, peripheral, and/or autonomic nervous systems. PNS in lymphoma is exceedingly rare and there is limited evidence on the features,
Jayesh Menon, Tyler Rehbein, Patrick Reagan, Carla Casulo, Kalyani Sen   +4 more
wiley   +1 more source