Results 51 to 60 of about 62,562 (262)

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Identification and Distribution of Begomoviruses Infecting Cassava Fields in Sierra Leone

Plants
A dearth of knowledge exists on identifying the begomoviruses and distributing cassava mosaic viruses across key cassava-growing regions of Sierra Leone.
Musa Decius Saffa, Alusaine Edward Samura, Mohamed Alieu Bah, Angela Obiageli Eni, Ezechiel B. Tibiri, Saïdou Zongo, William J.-L. Amoakon, Fidèle Tiendrébéogo, Justin Simon Pita, Prince Emmanuel Norman   +9 more
doaj   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Development and Application of Attenuated Plant Viruses as Biological Control Agents in Japan

Viruses
In 1929, it was reported that yellowing symptoms caused by a tobacco mosaic virus (TMV) yellow mosaic isolate were suppressed in tobacco plants that were systemically infected with a TMV light green isolate.
Yasuhiro Tomitaka, Yoshifumi Shimomoto, Bo-Song Ryang, Kazusa Hayashi, Tomoka Oki, Momoko Matsuyama, Ken-Taro Sekine   +6 more
doaj   +1 more source

Deteksi Virus Terbawa Umbi Benih pada Bawang Merah Kultivar Biru Bantul

Jurnal Fitopatologi Indonesia, 2017
Virus infection on shallots may cause mosaic of leaves and plant dwarf.  It is very important to know the identity of the virus as a requirement in determining viral disease management strategy.
Nurviani Nurviani, Sri Sulandari, Susamto Somowiyarjo, Siti Subandiyah   +3 more
doaj   +1 more source

Molecular Detection of Cucumber Mosaic Virus and Tobacco Mosaic Virus Infecting African Nightshades (Solanum scabrum Miller)

International Journal of Agronomy, 2020
The two viruses cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) are among the major viruses that constrain the production of African nightshade (ANS).
S. L. Kimaru, D. C. Kilalo, W. M. Muiru, J. W. Kimenju, C. R. Thuku   +4 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Movement of barley mild mosaic and barley yellow mosaic viruses in leaves and roots of barley

Annals of Applied Biology, 1995
SUMMARYLeaves of barley plants were mechanically inoculated with barley mild mosaic virus (BaMMV) and roots were inoculated using viruliferous zoospores of the fungus vector Polymyxa graminis. At intervals after inoculation, leaves and roots were tested by different methods to detect virus coat protein (ELISA or Western blot) or nucleic acid (slot‐blot
Schenk, PM, Antoniw, JF, Batista, MD, Jacobi, V, Adams, MJ, Steinbiss, HH   +5 more
openaire   +4 more sources

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source