Results 101 to 110 of about 42,857 (292)

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Memory Mosaics

CoRR
Memory Mosaics are networks of associative memories working in concert to achieve a prediction task of interest. Like transformers, memory mosaics possess compositional capabilities and in-context learning capabilities. Unlike transformers, memory mosaics achieve these capabilities in comparatively transparent way ("predictive disentanglement").
Jianyu Zhang, Niklas Nolte, Ranajoy Sadhukhan, Beidi Chen, Léon Bottou   +4 more
openaire   +4 more sources

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Pigmentary Mosaicism

Indian Journal of Paediatric Dermatology, 2023
Ratnakar Shukla, Chirag Desai
openaire   +2 more sources

Revertant mosaicism in epidermolysis bullosa.

, 2018
Revertant mosaicism in epidermolysis bullosa.
Hans Joenje (260225), Anna M. G. Pasmooij (4876045), Robert M. W. Hofstra (87569), Gerard J. te Meerman (87570), Peter C. van den Akker (4876048), Marcel F. Jonkman (426370)   +5 more
core   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Assessment of parental mosaicism rates in neurodevelopmental disorders caused by apparent de novo pathogenic variants using deep sequencing

Scientific Reports
While de novo variants (DNV) are overall at low risk of recurrence in subsequent pregnancies, a subset is at high risk due to parental mosaicism. Accurately identifying cases of parental mosaicism is therefore important for genetic counseling in clinical
François Lecoquierre, Kévin Cassinari, Nathalie Drouot, Angèle May, Steeve Fourneaux, Francoise Charbonnier, Celine Derambure, Sophie Coutant, Pascale Saugier-Veber, Alexander Hoischen, Camille Charbonnier, Gaël Nicolas   +11 more
doaj   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Elastomeric Core‐Conductive Shell Slurry Additive Stabilizes High‐Voltage NCM811 Cathodes via Mechanical‐Electrical Dual Regulation

Advanced Science, EarlyView.
A core‐shell ASA slurry additive constructs a mosaic‐like interface on high‐voltage NCM811 cathodes. This architecture decouples interfacial functions: the elastomeric core buffers mechanical stress to prevent microcracking, while the conductive shell facilitates rapid ion/electron transport, enabling mechanical‐electrical dual regulation and enhanced ...
Jiamin Duan, Xingchen Liu, Jiapei Li, Zhuijun Xu, Said Amzil, Baohu Wu, Yiyao Xiao, Wenjun Zhang, Tong Yu, Xiaohong Li, Wenwen Xue, Xiangyu Chen, Changwei Liu, Jie Gao, Peter Müller‐Buschbaum, Ya‐Jun Cheng, Yonggao Xia   +16 more
wiley   +1 more source

A rare case of uniparental disomy 9 concomitant with low-level mosaicism

Вавиловский журнал генетики и селекции
Uniparental disomy of chromosome 9, in combination with low-level mosaicism for chromosome 9, represents a rare chromosomal disorder. One of the mechanisms underlying the formation of uniparental disomy is the trisomy rescue, which concurrently results ...
A. S. Iakovleva, Zh. G. Markova, L. A. Bessonova, N. V. Shilova   +3 more
doaj   +1 more source