Results 121 to 130 of about 225,828 (274)
Advanced Science, EarlyView.This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei +10 more
wiley +1 more source
The motherhood penalty in the United Kingdom: An unconditional quantile regression analysis
International Labour ReviewUtilizing data from the UK Household Longitudinal Study, we employ panel methodologies and unconditional quantile regression (UQR) analysis to explore the prevalence and impact of the motherhood penalty within the context of the United Kingdom. Our panel
doaj +2 more sources
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
The Changing Pathways of Hispanic Youths Into Adulthood [PDF]
, 2009 Analyzes 1970-2007 census data for trends in skills acquisition, school enrollment, labor force participation, military enlistment, marriage and parenting, and incarceration among Latino youths.
Richard Fry
core
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
The Motherhood Wage Penalty in a Mediterranean Country: The Case of Spain [PDF]
We present evidence for the motherhood wage penalty in Spain as a representative Southern European Mediterranean country. We use the European Community Household Panel (ECHP, 1994-2001) to estimate, from both pool and fixed-effects methods, a wage ...
Molina, José Alberto +1 more
core
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
Advanced Science, EarlyView.The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen +12 more
wiley +1 more source
Motherhood in breast cancer survivors: Challenges and opportunitiesties [PDF]
Caspian Journal of Internal MedicineReproductive-aged breast cancer (BC) survivors have different ideas regarding the experience of motherhood after cancer treatment. Some BC survivors considered motherhood a miracle of God, an unexpected pleasant event, and an incredible opportunity to ...
Marzieh Azizi +5 more
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