Results 131 to 140 of about 1,795,685 (335)

Model selection and sensitivity analysis for sequence pattern models

, 2008
In this article we propose a maximal a posteriori (MAP) criterion for model selection in the motif discovery problem and investigate conditions under which the MAP asymptotically gives a correct prediction of model size. We also investigate robustness of
Gupta, Mayetri
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Mesin Ketik Huruf Braille ElektronikBerbasisMikrokontroler ATmega16 [PDF]

, 2012
Perhatian bagi para penyandang tuna netra saat ini masih kurang. Masih sangat jarang ditemui pengumuman publik atau sejenisnya dalam bentuk huruf braille.
Zaenal , Muttaqien
core  

Motif Discovery through Predictive Modeling of Gene Regulation

, 2005
We present MEDUSA, an integrative method for learning motif models of transcription factor binding sites by incorporating promoter sequence and gene expression data.
A. Battle, A.P. Gasch, C.E. Lawrence, E. Segal, E. Segal, E. Wingender, E.M. Conlon, G.Z. Hertz, H.J. Bussemaker, J.D. Hughes, N. Slonim, R.E. Schapire, T. Cover, T.I. Lee, T.L. Bailey, Y. Pilpel   +15 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

INTER ET INTRA TEXTE DANS NUIT RHÉNANE D’APOLLINAIRE [PDF]

Studii si Cercetari Filologice: Seria Limbi Romanice, 2010
Le poème Nuit rhénane est illustratif pour l’inspiration allemande du poète, qui construit son texte en se servant des légendes germaniques, sans se rapporter précisément à aucune d’entre elles ; il en recrée le cadre fantastique et en emprunte les ...
Alexandrina MUSTATEA
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Structure of the story in Qasas ul-Anbiya of Kisa'i (Stories of the Prophets) [PDF]

Matn/Pizhūhī-i Adabī, 2015
Qasas Ul Anbiya by Kisa'i is a works in Arabic by Muhammad b. Abdullah al-Kisa'i. The realidentityof itsauthoris not well known. This work is common in Islamiccommunities, especially among the public withnames such as“Bad’aldonya VA Qisas ul-Anbiya ...
Kazem Dezfolian, Gholamreza Rafiei
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source