Results 141 to 150 of about 1,795,685 (335)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
KONYA MERAM İLÇESİKARADİĞİN KASABASI’NDA KANAVİÇE İŞLEMELER
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2004 Anadolu’nun çeşitli yörelerinde tekniği aynı, fakat, motif, renk ve kompozisyon farklılıklarıile karşımıza çıkan kanaviçe işlemelerine; Konya Meram İlçesi Karadiğin Kasabası’nda rastlanmıştır.
Gülizar Altun
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A novel mode of capping protein-regulation by Twinfilin [PDF]
, 2018 Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery.
Amarasinghe, Gaya K +8 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Novel High Content Multi-Parametric Cell-Based Assays
BioTechniques, 2007 Chris Shumate +3 more
doaj +1 more source
Identifying vital nodes algorithm in social networks fusing higher-order information
Tongxin xuebao, 2019 Identifying vital nodes is a basic problem in complex network research.The existing theoretical framework,mainly considered from the lower-order structure of node-based and edge-based relations often ignores important factors such as interactivity and ...
Guanghui YAN +4 more
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Analysis of Analogies of Oriental Ornamentation in Russian Art of the XIV–XV Centuries
Археология евразийских степейIn the XIV–XV centuries decorative art is being revived in Rus, based on pre-Mongol samples. The main support remained Byzantine samples, where lush floral patterns and Arabic calligraphy continued to be used.
Natalya V. Zhilina
doaj +1 more source