Results 11 to 20 of about 1,000,669 (300)
Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem [PDF]
International Conference on Learning Representations, 2022 Construction of a scaffold structure that supports a desired motif, conferring protein function, shows promise for the design of vaccines and enzymes. But a general solution to this motif-scaffolding problem remains open.
Brian L. Trippe +6 more
semanticscholar +1 more source
Motif: Intrinsic Motivation from Artificial Intelligence Feedback [PDF]
International Conference on Learning Representations, 2023 Exploring rich environments and evaluating one's actions without prior knowledge is immensely challenging. In this paper, we propose Motif, a general method to interface such prior knowledge from a Large Language Model (LLM) with an agent. Motif is based
Martin Klissarov +7 more
semanticscholar +1 more source
Journal of Developmental Biology, 2021 Epigenetic modifications regulate gene expression for development, immune response, disease, and other processes. A major role of epigenetics is to control the dynamics of chromatin structure, i.e., the condensed packaging of DNA around histone proteins ...
Rwik Sen, Christopher Barnes
doaj +1 more source
Higher-order motif analysis in hypergraphs [PDF]
Communications Physics, 2021 A deluge of new data on real-world networks suggests that interactions among system units are not limited to pairs, but often involve a higher number of nodes.
Q. F. Lotito +3 more
semanticscholar +1 more source
Journal of Developmental Biology, 2021 Heart disease is the leading cause of death in the United States and worldwide. Understanding the molecular mechanisms of cardiac development and regeneration will improve diagnostic and therapeutic interventions against heart disease. In this direction,
Nicholas Francoeur, Rwik Sen
doaj +1 more source
International Journal for Innovation Education and Research, 2022 The popularization of online video platforms has also increased the number of producers who, with reduced teams or composed of a single person, have an inexperienced profile in this activity. Thus, among the various specificities of the material produced, the sound issue tends to be underestimated, sometimes harming the message to be transmitted.
Luiz Guilherme Marques +1 more
openaire +4 more sources
BioChem, 2021 In the race against COVID-19 for timely therapeutic developments, mass spectrometry-based high-throughput methods have been valuable. COVID-19 manifests an extremely diverse spectrum of phenotypes from asymptomatic to life-threatening, drastic elevations
Diane Appiasie +5 more
doaj +1 more source
Anchor-based bisulfite sequencing determines genome-wide DNA methylation
Communications Biology, 2022 Anchor-Based Bisulfite Sequencing (ABBS) is a sequencing based method that enables analysis of DNA methylation states, based on specific hybridization of bisulfite-refractory methylcytosines with 8-aza-7-deaza-2-deoxyguanosine, incorporated in a primer ...
Nathaniel Chapin +3 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2021 Objectives: This study examined the in vitro activity of iclaprim and comparators against 40 Listeria monocytogenes clinical isolates mostly (95%) from patients with bloodstream infection (BSI) from the USA, Australia/New Zealand, Latin America and ...
David B. Huang +5 more
doaj +1 more source
ELM—the Eukaryotic Linear Motif resource—2024 update
Nucleic Acids Research, 2023 Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as
Manjeet Kumar +24 more
semanticscholar +1 more source