Results 111 to 120 of about 539,525 (316)

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Nature Communications, 2018
Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to ...
Julien Robert-Paganin, Daniel Auguin, Anne Houdusse   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Combining endoscopic variceal ligation and omeprazole sodium in treating upper gastrointestinal hemorrhage combined with liver cirrhosis

BMC Gastroenterology
Background Cirrhosis, a common chronic liver disease, leads to portal hypertension and complications like ascites and variceal bleeding. Endoscopic variceal ligation (EVL) is the preferred treatment for variceal bleeding.
Changfang Xie, Shilei Gong, Zhenfeng Zhao, Lu Liu, Lu Lu, Jin Zhou, Xiaohuan Yu, Ying Xiong   +7 more
doaj   +1 more source

Green Endoscopy and Sustainable Practices: A Scoping Review

Journal of Digestive Endoscopy
Objectives The emergence of “green endoscopy” arises from the increasing global need to reform environmental sustainability due to climate change.
Thai Hau Koo, Vincent Tee, Yeong Yeh Lee, Nur Sakinah Roslan, Yusof Shuaib Ibrahim   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

The incretin hormones GIP and GLP-1 in diabetic rats : effects on insulin secretion and small bowel motility

, 2009
Incretin hormones often display inhibitory actions on gut motility. The aim of this study was to investigate if altered responsiveness to glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) as regards insulin release and ...
Hellstrom, PM, Edholm, T, Cejvan, K, Efendic, S, Schmidt, P T, Cejvan, Kenan, Abdel-Halim, S M, Abdel-Halim, SM, Hellström, Per M.,, Schmidt, PT   +9 more
core   +1 more source

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M.
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Long-term Prognosis and Prognostic Factors in Ineffective Esophageal Motility

Background/Aims Ineffective esophageal motility is the most frequent disorder of esophageal peristalsis. Symptoms may include dysphagia, chest pain, and heartburn. Our aims are to evaluate the long-term prognosis and determine if provocative tests during
Al-Oleiw, Yassir, Josefsson, Axel,, Demir, Daghan   +2 more
core   +1 more source