Results 121 to 130 of about 539,525 (316)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Peripheral cellular immune alterations during excessive alcohol consumption

Annals of Hepatology
Introduction and Objectives: The mechanisms that participate in the pathophysiology of chronic alcohol consumption and Alcoholic Liver Disease (ALD) include alterations of the innate and adaptive immune system, until now there is little information about
Karla Z. Medina-Avila, Abigail Hernandez-Barragan, Marisela Hernández-Santillan, Isabel Villagómez-López, Adrián Flores-Sanchez, Melanie Acosta-Gutiérrez, Viridiana Bautista-Nava, Isaac B Flores-Islas, Jesús A Dorantes-Álvarez, Moisés Martinez-Castillo, Fátima Higuera-de la Tijera, José L Pérez-Hernández, Gabriela Gutiérrez-Reyes   +12 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Clinical manifestations, and oxidative stress imbalance in children with obesity and MASLD

Annals of Hepatology
Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is often considered a multifactorial disease that has shown high incidence in recent years in both children and adults. To date, management criteria, diagnosis,
Isabel Villagómez-López, Laura Mejía-Pérez, Moisés Martínez-Castillo, Liliana Suárez-Bonilla, Daniel Santana-Vargas, Zaira Medina-Avila, Abigail Hernandez-Barragan, Jessica Limon-Castillo, Dana Mercado-Herrera, Gabriela Gutierrez-Reyes   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gut Neuropathies and Intestinal Motility Disorders

Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways.
Wattchow, David A., De Giorgio, Roberto, Dinning, Phil G., Brookes, Simon J. H., Spencer, Nick J., Costa, Marcello   +5 more
core   +1 more source

On the origins of the compressive cochlear nonlinearity [PDF]

, 2011
Various simple mathematical models of the dynamics of the organ of Corti in the mammalian cochlea are analysed. The models are assessed against their ability to explain the compressive nonlinear response of the basilar membrane.
Homer, ME, O Maoileidigh, Daibhid, Cooper, NP, Champneys, AR, Szalai, R, Kennedy, HJ   +5 more
core  

Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition

, 2018
In 2011, the Korean Society of Neurogastroenterology and Motility (KSNM) published clinical practice guidelines on the management of irritable bowel syndrome (IBS) based on a systematic review of the literature.
정혜경
core   +1 more source