Results 101 to 110 of about 435,922 (318)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Does irritable bowel syndrome really exist? Reactions to the proposed motility-based classification system [PDF]

, 2003
William E. Whitehead
openalex   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Coordinates and motility parameters from boar sperm exposed to various concentrations of ketanserin

, 2022
Andrés Martínez
openalex   +1 more source

Hepatic histologic findings in a murine model of diet induced-steatotic liver disease and acute alcohol intake

Annals of Hepatology
Introduction and Objectives: Steatotic liver disease is produced by a range of etiologic agents, among them metabolic and alcoholic. Our aim was to identify the histologic findings produced in the liver after the interaction of steatosis induced by the ...
Gabriela Sarahi Martínez-Mejia, Miriam G. Bautista-Ubaldo, Gabriela Gutiérrez-Reyes, Carolina Guzmán   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Physiology of Gastrointestinal Motility [PDF]

, 2001
Peter J. Milla
openalex   +1 more source

Evaluation of oxidative stress according to the pattern of alcohol consumption and in alcoholic liver disease.

Annals of Hepatology
Introduction and Objectives: Alcohol and its metabolites induce damage in the liver, such as: activation of the immune response and oxidative stress.
Adrián Flores-Sánchez, Abigail Hernández-Barragán, Daniela Colector-Sesatti, Andrea Garcia-Avalos, Moisés Martínez-Castillo, Marisela Hernández-Santillan, Jaqueline Córdova-Gallardo, José L. Pérez-Hernandez, Fátima Higuera-De la Tijera, Gabriela Gutiérrez-Reyes   +9 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis

Biomolecules
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. EoE shares a common pathogenetic mechanism with other chronic disorders pertaining to the type 2 inflammatory spectrum, such as atopic dermatitis (AD), allergic rhinitis (
Alberto Barchi, Francesco Vito Mandarino, Mona-Rita Yacoub, Luca Albarello, Luca Massimino, Edoardo Vincenzo Savarino, Federica Ungaro, Sandro Passaretti, Gwen M. C. Masclee, Silvio Danese, Albert J. Bredenoord, Edoardo Vespa   +11 more
doaj   +1 more source