Results 81 to 90 of about 597,542 (311)

Esophageal High Pressure Zones: Effect of Perisophageal Structures on Esophageal Manometric Recording

Canadian Journal of Gastroenterology, 1994
During the course of esophageal motility studies, short zones of elevated esophageal baseline pressure are occasionally noticed. The aim of this study is to determine their frequency and their cause. Among 77 consecutive esophageal manometries (group 1),
G Bédard, A Pellicano, R Ste-Marie
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction

Nature Communications
Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-cardiac myosin ...
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse   +8 more
doaj   +1 more source

Differences in the progression of liver disease in male and female rats induced by TAA: considerations in the development of pharmacological therapies

Annals of Hepatology
Introduction and Objectives: Thioacetamide (TAA) is a hepatotoxic agent that causes fibrosis, cirrhosis, and cancer. Various doses and regimens of TAA have been tested in different murine models to validate hepatoprotective compounds.
Jesús Dorantes-Alvarez, Moisés Martínez-Castillo, Adrián Flores-Sánchez, Ángel García-López, Luz Castro-Hernández, Abigail Hernandez-Barragan, Marisela Hernández-Santillán, Gabriela Gutierrez-Reyes   +7 more
doaj   +1 more source

Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

Journal of Translational Medicine, 2017
BackgroundThe gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined.
X. Ge, Chao Ding, Wei Zhao, Lizhi Xu, H. Tian, J. Gong, Min-Sheng Zhu, Jie‐shou Li, Ning Li   +8 more
semanticscholar   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Binocular and Fellow Eye Acuity Deficits in Amblyopia: Impact of Fixation Instability and Sensory Factors

Journal of Eye Movement Research
Amblyopia, a neurodevelopmental disorder, is commonly assessed through amblyopic eye visual acuity (VA) deficits, but recent studies also highlight abnormalities in the fellow eye. This study quantified binocular and fellow/dominant eye VA in individuals
Yulia Haraguchi, Gokce Busra Cakir, Aasef Shaikh, Fatema Ghasia   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Effects of visual blur on microsaccades during visual exploration

Journal of Eye Movement Research, 2019
Microsaccades shift the image on the fovea and counteract visual fading. They also serve as an optimal sampling strategy while viewing complex visual scenes. Microsaccade production relies on the amount of retinal error or acuity demand of a visual task.
Sherry Tang, Peggy Skelly, Jorge Otero-Millan, Jonathan Jacobs, Jordan Murray, Aasef G. Shaikh, Fatema F. Ghasia   +6 more
doaj   +1 more source