Results 81 to 90 of about 539,525 (316)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical Practice Guidelines for Functional Dyspepsia in Korea

, 2021
Functional dyspepsia (FD) is a chronic upper gastrointestinal (GI) symptom complex that routine diagnostic work-up, such as endoscopy, blood laboratory analysis, or radiological examination, fails to identify a cause.
태정현, 정혜경
core   +1 more source

Exposure to outdoor artificial light at night is associated with a higher risk of ulcerative colitis: a prospective cohort study from the UK Biobank

Frontiers in Public Health
BackgroundInflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, and environmental factors are believed to play an important role in its pathogenesis.
Jiamiao Chen, Jiamiao Chen, Laifu Li, Laifu Li, Yan Ran, Yan Ran, Zhuoya Sun, Zhuoya Sun, Shiwei Lu, Shiwei Lu, Yan Zhuang, Yan Zhuang, Lianli Wang, Lianli Wang, Yating Sun, Yating Sun, Fei Dai, Fei Dai   +17 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Speed effects in gliding motility assays due to surface passivation, water isotope, and osmotic stress. [PDF]

, 2010
The molecular motor kinesin-1, an ATPase, and the substrate it walks along, microtubules, are vital components of eukaryotic cells. Kinesin converts chemical energy to linear motion as its two motor domains step along microtubules in a process similar to
Steven J. Koch, Andy Maloney, Lawrence J. Herskowitz   +2 more
core   +1 more source

European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID‐19 pandemic [PDF]

, 2020
Background: During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended.
Pohl D., Drewes A., Dickman R., Cremon C., Stanghellini V., Hauser G., Londoni C., Enck P., Azpiroz F., Marabotto E., Baldi F., Suarez J. F., Novais L., Geeraerts A., Barba E., Costantini M., Farmer A., Mulak A., Barbara G., Tack J., Bellini M., Cataudella G., Ruiz de Leon A., Schol J., Accarino A., Vanuytsel T., Carbone F., Bor S., Serra J., Drug V., Salvador R., Zerbib F., Mas P., Savarino E., Perez de la Serna J., Altomare A., Casa D. D., Iovino P., Storonova O., Tolone S., Alcedo J., Farmer, Adam, Carbone, Florencia, Hauser, Goran, Stanghellini, Vincenzo, Serra, J., Tim Vanuytsel, Alcedo, Javier, Renato Salvador, Giovanni Barbara, Cremon, Cesare, Mas, Pilar, Accarino, Anna, Drug, Vasile, Novais, Luis, Tack, Jan,, Edoardo Savarino, Costantini, Mario, Anna Accarino, Vanuytsel, T., Marabotto, Elisa, Cataudella, Giovanni, Savarino, Edoardo, Baldi, Fabio, Bor, Serhat, Serra, Jordi, Vincenzo Stanghellini, Zerbib, Frank, Ruiz de León, Antonio, Barbara, G., Altomare, Annamaria, Enck, Paul, Tolone, Salvatore, Tack, Jan, Geeraerts, Annelies, Accarino, A., Drewes, Asbjørn, Vanuytsel, Tim, Londoni, Claudio, Storonova, Olga, Barba, Elisabeth, Azpiroz, Fernando, Schol, Jolien, Mario Costantini, Jan Tack, Suárez, José F., Barbara, Giovanni, Casa, Domenico Della, Pohl, Daniel, Mulak, Agata, Jordi Serra, Salvador, Renato, Dickman, Ram, Iovino, Paola, Stanghellini, V., Pérez de la Serna, Julio, Bellini, Massimo   +96 more
core   +1 more source

Binocular and Fellow Eye Acuity Deficits in Amblyopia: Impact of Fixation Instability and Sensory Factors

Journal of Eye Movement Research
Amblyopia, a neurodevelopmental disorder, is commonly assessed through amblyopic eye visual acuity (VA) deficits, but recent studies also highlight abnormalities in the fellow eye. This study quantified binocular and fellow/dominant eye VA in individuals
Yulia Haraguchi, Gokce Busra Cakir, Aasef Shaikh, Fatema Ghasia   +3 more
doaj   +1 more source

Automatic diagnosis of extraocular muscle palsy based on machine learning and diplopia images [PDF]

International Journal of Ophthalmology
AIM: To develop different machine learning models to train and test diplopia images and data generated by the computerized diplopia test. METHODS: Diplopia images and data generated by computerized diplopia tests, along with patient medical records, were
Xiao-Lu Jin, Xue-Mei Li, Tie-Juan Liu, Ling-Yun Zhou   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Abnormal small bowel motility in patients with hereditary transthyretin amyloidosis

, 2018
Background: Gastrointestinal complications are common in hereditary transthyretin amyloid (ATTRm) amyloidosis. The underlying mechanisms have not been fully elucidated, and the patients' small bowel function remains largely unexplored.
Wixner, J, Lindberg, G,, Karling, Pontus,, Lindberg, G., Karling, Pontus, Törnblom, Hans,, P. Karling, Anan, Intissar, Anan, I, Karling, P, J. Wixner, Karling, P., Tornblom, H, Wixner, Jonas,, Anan, I., Wixner, Jonas, I. Anan, H. Törnblom, Wixner, J., Anan, Intissar,, Törnblom, H., G. Lindberg   +21 more
core   +1 more source