Results 71 to 80 of about 597,542 (311)

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exposure to outdoor artificial light at night is associated with a higher risk of ulcerative colitis: a prospective cohort study from the UK Biobank

Frontiers in Public Health
BackgroundInflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, and environmental factors are believed to play an important role in its pathogenesis.
Jiamiao Chen, Jiamiao Chen, Laifu Li, Laifu Li, Yan Ran, Yan Ran, Zhuoya Sun, Zhuoya Sun, Shiwei Lu, Shiwei Lu, Yan Zhuang, Yan Zhuang, Lianli Wang, Lianli Wang, Yating Sun, Yating Sun, Fei Dai, Fei Dai   +17 more
doaj   +1 more source

The myosin X motor is optimized for movement on actin bundles

Nature Communications, 2016
Myosin X is a molecular motor unique in its ability to generate filopodia, but the mechanism explaining this behaviour is not known. Here, through a combination of structure, single-molecule assays and modelling the authors show that myosin X is ...
Virginie Ropars, Zhaohui Yang, Tatiana Isabet, Florian Blanc, Kaifeng Zhou, Tianming Lin, Xiaoyan Liu, Pascale Hissier, Frédéric Samazan, Béatrice Amigues, Eric D. Yang, Hyokeun Park, Olena Pylypenko, Marco Cecchini, Charles V. Sindelar, H. Lee Sweeney, Anne Houdusse   +16 more
doaj   +1 more source

Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium

Neurogastroenterology and Motility, 2019
Ineffective esophageal motility (IEM) is a heterogenous minor motility disorder diagnosed when ≥50% ineffective peristaltic sequences (distal contractile integral
C. Gyawali, D. Sifrim, D. Carlson, M. Hawn, D. Katzka, J. Pandolfino, R. Penagini, S. Roman, E. Savarino, R. Tatum, M. Vaezi, J. Clarke, G. Triadafilopoulos   +12 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Automatic diagnosis of extraocular muscle palsy based on machine learning and diplopia images [PDF]

International Journal of Ophthalmology
AIM: To develop different machine learning models to train and test diplopia images and data generated by the computerized diplopia test. METHODS: Diplopia images and data generated by computerized diplopia tests, along with patient medical records, were
Xiao-Lu Jin, Xue-Mei Li, Tie-Juan Liu, Ling-Yun Zhou   +3 more
doaj   +1 more source

Endocytic reawakening of motility in jammed epithelia

Nature Materials, 2017
Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or rigidity transition. How cells control such phase transitions is, however, unknown.
C. Malinverno, Salvatore Corallino, F. Giavazzi, M. Bergert, Qingsen Li, M. Leoni, Andrea Disanza, E. Frittoli, A. Oldani, Emanuele Martini, Tobias Lendenmann, Gianluca Deflorian, G. Beznoussenko, D. Poulikakos, Ong Kok Haur, Marina Uroz, X. Trepat, D. Parazzoli, P. Maiuri, Weimiao Yu, A. Ferrari, R. Cerbino, G. Scita   +22 more
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source