Results 71 to 80 of about 539,525 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Effects of an Extract of Atractylodes Japonica Rhizome, SKI3246 on Gastrointestinal Motility in Guinea Pigs [PDF]

, 2015
BACKGROUND/AIMS: There are limited therapeutic options available for irritable bowel syndrome with diarrhea (IBS-D). We tested the effects of Atractylodes japonica rhizome, a perennial plant native to North Asia, on both upper and lower gastrointestinal (
박재준, 전누리, 박효진
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

, 2021
The Korean Society of Neurogastroenterology and Motility first published guidelines for chronic constipation in 2005 and was updated in 2011. Although the guidelines were updated using evidence-based process, they lacked multidisciplinary participation ...
정순섭, 정혜경
core   +1 more source

The Pathophysiology of Chronic Constipation

Canadian Journal of Gastroenterology, 2011
Constipation is broadly defined as an unsatisfactory defecation characterized by infrequent stools, difficult stool passage or both. The common approach to the pathophysiology of constipation groups the disorder into primary and secondary causes. Primary
Christopher N Andrews, Martin Storr
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Water Flux in Cell Motility : Expanding the Mechanisms of Membrane Protrusion

, 2009
Transmembrane water fluxes through aquaporins (AQPs) are suggested to play, pivotal roles in cell polarization and directional cell motility. Local dilution by W water influences the dynamics of the subcortical actin polymerization and directs the ...
Magnusson, Karl-Eric,, Karlsson, Thommie,, Loitto, Vesa,   +2 more
core   +1 more source

The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori [PDF]

, 2010
Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa.
Caly, Delphine L., O\u27Toole, Paul W., Penn Charles W, Stanley A Moore, Douillard, FP, Douillard, François P., Ryan, KA, Caly Delphine L, Hinds, Jason, Francois P Douillard, Charles W Penn, Moore, SA, Paul W O'Toole, Moore Stanley A, Lane, Michael C., Hinds Jason, Kieran A Ryan, Ryan Kieran A, Lane Michael C, Michael C Lane, Delphine C Caly, O'Toole Paul W, O'Toole, PW, Ryan, Kieran A., Penn, Charles, Caly, DL, Hinds, J, Penn, CW, Penn, Charles W., Jason Hinds, Lane, MC, Moore, Stanley A., Douillard François P, O'Toole, Paul W., Penn, Charles W, Moore, Stanley A, Caly, Delphine C, Lane, Michael C, Ryan, Kieran A, Douillard, Francois P, O'Toole, Paul W   +40 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A survey on the impact of the COVID‐19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase

, 2020
BACKGROUND: The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the ...
Geeraerts, A., Pieter Sinonquel, Lucas Wauters, Colomier, E., Lien Timmermans, Tim Vanuytsel, Jandee, S., Hideki Mori, Hannelore Geysen, Wout Verbeure, Nathalie Rommel, Carbone, F., Magnus Simren, Annelies Geeraerts, Hoffman, I., Karen Van den Houte, Simrén, Magnus,, Verbeke, K., Mori, H., An Moonen, Timmermans, L., Suzuki, H., Törnblom, Hans,, Pannemans, J., Geysen, H., Tack, Jan,, Wauters, L., Ilse Hoffman, Philip Roelandt, van den Houte, K., Bisschops, R., Esther Colomier, Rommel, N., Kristin Verbeke, Moonen, A., Scarpellini, E., Verbeure, W., Jan Tack, Vanuytsel, T., Schol, J., Emidio Scarpellini, Roelandt, P., Huang, I. H., Hidekazu Suzuki, Sawangpong Jandee, Florencia Carbone, Sinonquel, P., Jolien Schol, Hans Tornblom, Jasper Pannemans, I‐Hsuan Huang, Raf Bisschops   +51 more
core   +1 more source