Results 61 to 70 of about 742,756 (306)

STATINS, MYOPATHY AND PHYSICAL ACTIVITY

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae, 2018
Background: Cholesterol-lowering therapy (statins), associated with lifestyle modifications, have an important role in reducing atherosclerotic cardiovascular disease (ASCVD) events.
Elena SÎRBU, Șerban GLIGOR
doaj   +1 more source

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Keiser, Jennifer, Tritten, Lucienne, Wimmersberger, David   +2 more
core   +2 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Nature Communications, 2023
To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M. Ruppel, James A. Spudich, Anne Houdusse, Julien Robert-Paganin   +10 more
doaj   +1 more source

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
A Fenwick, AA Sayed, B Gryseels, B Ramirez, CE Cousin, CJ Murray, E Groll, Gordana Panic, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Utzinger, J Utzinger, JB Correa Soares, Jennifer Keiser, K Ingram, K Ingram, K Waisser, Katrin Ingram-Sieber, L Pica-Mattoccia, MH Abdulla, Mireille Vargas, Noemi Cowan, NR Mansour, Nuha R. Mansour, P Steinmann, Quentin D. Bickle, RA Paveley, S Denoyelle, S Knopp, SD Melman, SH Xiao, SH Xiao, SH Xiao, T Chen, T Manneck, T Spangenberg, Thomas Spangenberg, Timothy G. Geary, Timothy N. C. Wells   +42 more
core   +5 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

The myosin X motor is optimized for movement on actin bundles

Nature Communications, 2016
Myosin X is a molecular motor unique in its ability to generate filopodia, but the mechanism explaining this behaviour is not known. Here, through a combination of structure, single-molecule assays and modelling the authors show that myosin X is ...
Virginie Ropars, Zhaohui Yang, Tatiana Isabet, Florian Blanc, Kaifeng Zhou, Tianming Lin, Xiaoyan Liu, Pascale Hissier, Frédéric Samazan, Béatrice Amigues, Eric D. Yang, Hyokeun Park, Olena Pylypenko, Marco Cecchini, Charles V. Sindelar, H. Lee Sweeney, Anne Houdusse   +16 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Reactivation of ethanol-calcium-isolated cilia from Tetrahymena pyriformis [PDF]

, 1967
Cilia isolated from Tetrahymena after ciliary shedding is induced by the addition of CaCl2 or other salts to cells suspended in an ethanol solution (4, 6, 11) have been studied chemically and enzymatically (4, 6, 11, 12, 13), but until now have never ...
Winicur, Sandra
core   +2 more sources