The myosin X motor is optimized for movement on actin bundles
Nature Communications, 2016 Myosin X is a molecular motor unique in its ability to generate filopodia, but the mechanism explaining this behaviour is not known. Here, through a combination of structure, single-molecule assays and modelling the authors show that myosin X is ...
Virginie Ropars +16 more
doaj +1 more source
Selecting active matter according to motility in an acoustofluidic setup: Self-propelled particles and sperm cells [PDF]
Soft Matter 19, 8635-8648 (2023)Active systems -- including sperm cells, living organisms like bacteria, fish, birds, or active soft matter systems like synthetic ''microswimmers'' -- are characterized by motility, i.e., the ability to propel using their own ''engine''. Motility is the key feature that distinguishes active systems from passive or externally driven systems. In a large
arxiv +1 more source
Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading [PDF]
, 2007 Actin-based motility is central to cellular processes such as migration, bacterial engulfment, and cancer metastasis, and requires precise spatial and temporal regulation of the cytoskeleton.
Anna H. Shneidman +8 more
core +1 more source
Spontaneous symmetry breaking in active droplets provides a generic route to motility
, 2012 We explore a generic mechanism whereby a droplet of active matter acquires motility by the spontaneous breakdown of a discrete symmetry. The model we study offers a simple representation of a "cell extract" comprising, e.g., a droplet of actomyosin ...
Cates, M. E., Marenduzzo, D., Tjhung, E.
core +1 more source
α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. [PDF]
, 2016 Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient ...
Atabai, Kamran +12 more
core +2 more sources
Extraocular Muscle Imbalance and Outcomes of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment [PDF]
, 2020 Objective: The objective was to study the muscle imbalance, restrictive motility in unlike gazes and the outcomes of the scleral buckling surgery for rhegmatogenous retinal detachment.
Kawish, A. B. (Ayesha) +2 more
core +1 more source
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity
Cell Death and Disease, 2017 Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
P. Bhat +3 more
semanticscholar +1 more source
Symmetry-breaking motility of penetrable objects in active fluids [PDF]
arXiv, 2023 We investigate how a symmetric penetrable object immersed in an active fluid becomes motile due to a negative drag acting in the direction of its velocity. While similar phenomena have been reported only for active fluids that posses polar or nematic order, we demonstrate that such motility can occur even in active fluids without any preexisting order.
arxiv
Diffusive transport without detailed balance in motile bacteria: Does microbiology need statistical physics? [PDF]
Reports on Progress in Physics, 75, 042601 (2012), 2012 Microbiology is the science of microbes, particularly bacteria. Many bacteria are motile: they are capable of self-propulsion. Among these, a significant class execute so-called run-and-tumble motion: they follow a fairly straight path for a certain distance, then abruptly change direction before repeating the process.
arxiv +1 more source
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans [PDF]
, 2006 Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying.Aims: To assess the effects of endogenous GLP-1 on endocrine pancreatic ...
Göke, Burkhard +6 more
core +2 more sources