Results 71 to 80 of about 769,499 (354)

Correlations between the clinical characteristics of diabetic trochlear nerve palsy and diplopia severity

BMC Ophthalmology
Importance Few literatures reported the clinical characteristics of diabetic trochlear nerve palsy, including demographic characteristics, involvement between both eyes, time of symptom onset, duration of diabetes, etc. Whether there is relevance between
Zhaowen Xue, Tianxiang Cao, Xuemei Li, Deyu Hu, Yuan Li, Lingyun Zhou   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A self-driven phase transition drives Myxococcus xanthus fruiting body formation [PDF]

, 2019
Combining high-resolution single cell tracking experiments with numerical simulations, we show that starvation-induced fruiting body (FB) formation in Myxococcus xanthus is a phase separation driven by cells that tune their motility over time.
Bahar, Fatmagul, Liu, Guannan, Marchetti, M. Cristina, Patch, Adam, Shaevitz, Joshua W., Thutupalli, Shashi, Welch, Roy D., Yllanes, David   +7 more
core   +2 more sources

The Pathophysiology of Chronic Constipation

Canadian Journal of Gastroenterology, 2011
Constipation is broadly defined as an unsatisfactory defecation characterized by infrequent stools, difficult stool passage or both. The common approach to the pathophysiology of constipation groups the disorder into primary and secondary causes. Primary
Christopher N Andrews, Martin Storr
doaj   +1 more source

STATINS, MYOPATHY AND PHYSICAL ACTIVITY

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae, 2018
Background: Cholesterol-lowering therapy (statins), associated with lifestyle modifications, have an important role in reducing atherosclerotic cardiovascular disease (ASCVD) events.
Elena SÎRBU, Șerban GLIGOR
doaj   +1 more source

P-27 CELLULAR EFFECTS OF IN VITRO LIPID OVERLOAD ON HEPATIC STELLATE CELLS AND HEPATOCYTES.

Annals of Hepatology, 2023
Introduction and Objectives: Hepatic cells undergo different processes in response to the steatogenic input of MAFLD. Hepatic cell culture in steatogenic medium is a useful, reproducible tool intended to elucidate these pathogenic mechanisms.
Adriana Campos-Espinosa, José Luis Pérez-Hernández, Gabriela Gutiérrez-Reyes, Carolina Guzmán   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Nature Communications, 2023
To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M. Ruppel, James A. Spudich, Anne Houdusse, Julien Robert-Paganin   +10 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source