Results 121 to 130 of about 685,288 (265)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Design and Development of Rehabi, a mHealth Telerehabilitation Platform with Markerless Motion Analysis. [PDF]

Bioengineering (Basel)
González-Mendoza A, Aguilar-Sierra H, Zepeda-Mora R, Alessi-Montero A, Rodríguez-Reyes G, Carrera LN, Quiñones-Uriostegui I, Ayala-Cadena P, Gomez-Verdad A.   +8 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Sensor-based motion analysis for dementia detection: a systematic review. [PDF]

Front Digit Health
Jiang Z, Ghahramani M, D'Cunha NM, Fernandez Rojas R.   +3 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

A systematic review and meta-analysis on dual-task sensor-based motion analysis for dementia detection. [PDF]

Front Digit Health
Hosseini I, Northey JM, D'Cunha NM, Fernandez Rojas R, Shrestha A, Ghahramani M.   +5 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

In-Vivo 6D Heart Motion Analysis for Emerging Self-Powered Cardiac Implants. [PDF]

Ann Biomed Eng
Hasani M, Huber J, Kjærgaard B, Zaremba T, Rezania A, Riahi S.   +5 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Reliability assessment of markerless technologies in biomechanical motion analysis: a performance comparison. [PDF]

Front Sports Act Living
Balci IC, Sayin I, Salturk S, Gursoy R, Ozsoy U, Dogru HC, Akca G, Eraslan A, Sahin O, Demircali AA, Uvet H.   +10 more
europepmc   +1 more source