Results 61 to 70 of about 23,735,145 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On singular values decomposition and patterns for human motion analysis and simulation [PDF]
, 2012 We are interested in human motion characterization and automatic motion simulation. The apparent redun- dancy of the humanoid w.r.t its explicit tasks lead to the problem of choosing a plausible movement in the framework of redun- dant kinematics.
Chiron, Pascale +5 more
core +1 more source
Stability Control of a Biped Robot on a Dynamic Platform Based on Hybrid Reinforcement Learning
Sensors, 2020 In this work, we introduced a novel hybrid reinforcement learning scheme to balance a biped robot (NAO) on an oscillating platform, where the rotation of the platform is considered as the external disturbance to the robot. The platform had two degrees of
Ao Xi, Chao Chen
doaj +1 more source
Global Motion Model for Stereovision-Based Motion Analysis [PDF]
EURASIP Journal on Advances in Signal Processing, 2006 Summary: An advantage of stereovision-based motion analysis is that the depth information is available, thus motion can be estimated more precisely in 2.5D stereo coordinate system (SCS) constructed by the depth and the image coordinates. In this paper, stereo global motion in SCS, which is induced by 3D camera motion in real-world coordinate system ...
Hu Zhencheng +3 more
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Automated markerless analysis of human gait motion for recognition and classification
, 2011 We present a new method for an automated markerless system to describe, analyze, and classify human gait motion. The automated system consists of three stages: i) detection and extraction of the moving human body and its contour from image sequences, ii)
yoo, jang hee +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Computational structure of a biological motion-detection system as revealed by local detector analysis in the fly's nervous system [PDF]
, 1989 Egelhaaf M, Borst A, Reichardt W. Computational structure of a biological motion-detection system as revealed by local detector analysis in the fly's nervous system. Journal of the Optical Society of America, A: Optics, Image Science, and Vision.
Egelhaaf, M. +5 more
core +1 more source