Results 71 to 80 of about 59,454 (269)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Sacral Geography as a System: Problem of Sacral Object’s Status
Научный диалог, 2018 The author proposes to consider the revered loci of a particular area as a system, the elements of which are not isolated from each other, but demonstrate the relationship.
A. P. Lipatova
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Boundary motive, relative motives and extensions of motives
, 2010 46 pages; final ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Phenomenon of Transfiguration and System of Motifs in I. S. Shmelev’s Story “The Kulikovo Field”
Научный диалог, 2017 The article presents an analysis of motives that permeate the narrative in the story by Ivan Shmelev “The Kulikovo Field.” The author identified a number of motives, which semantics and functioning is interpreted at subject-figurative, symbolic, thematic
E. V. Paraskeva
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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THE MITHOPOETICS OF THE STORY V. DROZD «IRIY» / МІФОПОЕТИКА ПОВІСТІ В. ДРОЗДА «ИРІЙ»
Актуальні питання суспільних наук та історії медицини, 2018 В статье предпринята попытка системно проанализировать повесть В. Дрозда «Ирий» сквозь призму мифопоэтики, выявить образы, временно- пространственные модели и ценностные установки, которые тесно связаны со сказочно-мифологической традицией и ...
Людмила ГОЛОВКО +1 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2016 This article represents the interdisciplinary research made with linguistic, psycholinguistic and psychological methods. In the article the structuredness of notion "kindness" in the consciousness of hard-of-hearing and hearing teenagers is revealed ...
Nina Ivanovna Kolodina
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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