Results 81 to 90 of about 862,527 (298)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Precautionary Saving and Consumption Smoothing Across Time and Possibilities [PDF]

This paper examines how aversion to risk and aversion to intertemporal substitution determine the strength of the precautionary saving motive in a two-period model with Selden/Kreps-Porteus preferences.
Miles Kimball, Philippe Weil
core  

Special L-values of t-motives: a conjecture

, 2008
We propose a conjecture on special values of $ L $-functions in a function field context with positive characteristic coefficients. For $ M $ a uniformizable $ t $-motive with everywhere good reduction we conjecture a relation between the value of the ...
Anderson, Anderson, Anderson, Anderson, Beĭlinson, Deligne, Drinfel'd, Gardeyn, Gardeyn, Goss, Kontsevich, Lafforgue, Lenny Taelman, Milne, Russell, Schneider, Scholl, Serre, Stalder, Taelman, Taelman, Taguchi   +21 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The theme of the North in modern Russian folk-horror

RUDN Journal of Studies in Literature and Journalism
Examines the specifics of the implementation of the North theme in the subgenre of modern domestic folk horror using the example of novels and stories by D. Bobyleva, O. Kozhin, L. Lvova, A. Podolsky, M. Romanova.
Elena A. Safron
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Aspirations, Habit Formation, and Bequest Motive [PDF]

We analyze how the presence of endogenous preferences affects the altruistic bequest motive from parents to children. We will show that the existence of habits raises the threshold value of the intergenerational discount factor above which altruistic ...
Jaime Alonso-Carrera, Jordi Caballé, Xavier Raurich   +2 more
core  

t-Motives

Duke Mathematical Journal, 1986
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sacral Geography as a System: Problem of Sacral Object’s Status

Научный диалог, 2018
The author proposes to consider the revered loci of a particular area as a system, the elements of which are not isolated from each other, but demonstrate the relationship.
A. P. Lipatova
doaj   +1 more source