Results 81 to 90 of about 59,454 (269)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MOTIVATION OF STUDENTS TO LEARN: SOCIAL AND PSYCHOLOGICAL ASPECT
Вестник университета, 2019 Now a serious social and psychological problem of motivation to training is the fact that students «at any cost» and on any terms are necessary for higher education institutions.
N. Gerasimenko
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Underlying the Riemann Hypothesis there is a question whose full answer still eludes us: what do the zeros of the Riemann zeta function really mean? As a step toward answering this, André Weil proposed a series of conjectures that include a simplified version of the Riemann Hypothesis in which the meaning of the zeros becomes somewhat easier to ...
openaire +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Psychological Aspects of Preschoolers’ Perception and Understanding of the Main Cartoon Characters
Вестник Московского университета. Серия 14: ПсихологияBackground. The shortage of research on children’s perception of cartoons at preschool age defines the special relevance of the work. Objective. The work is aimed at identifying the peculiarities of preschoolers’ perception and understanding of the ...
Vladimir S. Sobkin +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
T. Wilder's Play “Our Town” in the Context of A. Chekhov's Dramaturgy
Pitannâ Lìteraturoznavstva, 2018 The research is connected with a new approach to understanding the poetics of T. Wilder's play “Our Town” (1938). The comparative and intertextual methods of research are applied.
Valentyna Borbuniuk
doaj
Bulletin of Kharkiv National University of Internal AffairsThe article is devoted to the study of the mechanism of individual criminal behaviour, which manifested itself in the seizure of the Chornobyl nuclear power plant by russian military personnel and occupation of the adjacent territory.
A. A. Ternavska
doaj +1 more source