Results 101 to 110 of about 925,078 (312)

Middle Ear Myoclonus: Two Informative Cases and a Systematic Discussion of Myogenic Tinnitus

Tremor and Other Hyperkinetic Movements, 2013
Background: The term middle ear myoclonus (MEM) has been invoked to explain symptoms of tinnitus presumably caused by the dysfunctional movement of either of the two muscles that insert in the middle ear: tensor tympani and stapedius.
Aviva Ellenstein, Nadia Yusuf, Mark Hallett   +2 more
doaj   +1 more source

Developmental motor profile in preschool children with primary stereotypic movement disorder [PDF]

, 2019
Aim. Different neuropsychological dysfunctions have been described in children with primary Stereotypic Movement Disorder (SMD), mainly attention or motor coordination problems.
Baglioni, Valentina, Caravale, Barbara, Cardona, Francesco, Chiarotti, Flavia, Pesola, Chiara, Teresa Giannini, Maria, Valente, Francesca   +6 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Computations of uncertainty mediate acute stress responses in humans

Nature Communications, 2016
Acute stress has broad physiological and behavioural consequences, yet the precise factors that generate stress responses are not known. Here, de Berker and colleagues demonstrate that acute stress responses dynamically track environmental uncertainty ...
Archy O. de Berker, Robb B. Rutledge, Christoph Mathys, Louise Marshall, Gemma F. Cross, Raymond J. Dolan, Sven Bestmann   +6 more
doaj   +1 more source

Treatment of Essential Tremor with Long-chain Alcohols: Still Experimental or Ready for Prime Time?

Tremor and Other Hyperkinetic Movements, 2014
Aim: To review current literature on long‐chain alcohols and their derivatives as novel pharmacotherapy for the treatment of essential tremor (ET). Background: Currently available and recommended pharmacotherapies for ET are often limited ...
Dietrich Haubenberger, Fatta B. Nahab, Bernhard Voller, Mark Hallett   +3 more
doaj   +1 more source

Convolutional Neural Network for Stereotypical Motor Movement Detection in Autism [PDF]

, 2015
Autism Spectrum Disorders (ASDs) are often associated with specific atypical postural or motor behaviors, of which Stereotypical Motor Movements (SMMs) have a specific visibility.
Bizzego, Andrea, Furlanello, Cesare, Jurman, Giuseppe, Kia, Seyed Mostafa, Rad, Nastaran Mohammadian, Venuti, Paola   +5 more
core   +1 more source

Brain tissue properties differentiate between motor and limbic basal ganglia circuits [PDF]

, 2014
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize ...
Accolla, EA, Chowdhury, R, Draganski, B, Dukart, J, Haynes, J-D, Helms, G, Hetzer, S, Kherif, F, Kühn, AA, Lutti, A, Weiskopf, N   +10 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source