Results 81 to 90 of about 502,314 (315)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Motor speech disorders in Chinese [PDF]

, 2014
Chinese, spoken by approximately 20% of the world’s population, is the most commonly spoken language in the world (Fung, 1990). There is some debate regarding whether varieties of spoken Chinese should be considered dialects or separate language.
Whitehill, T L, Whitehill, T. L., Ma, Joan K-Y, Whitehill, Tara L.   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation

Brain Stimulation, 2020
Background: Neuroimaging technology is being developed to enable non-invasive mapping of the latency distribution of cortical projection pathways in white matter, and correlative clinical neurophysiological techniques would be valuable for mutual ...
Zhen Ni, Giorgio Leodori, Felipe Vial, Yong Zhang, Alexandru V. Avram, Sinisa Pajevic, Peter J. Basser, Mark Hallett   +7 more
doaj   +1 more source

Characterizing intonation deficit in motor speech disorders : an autosegmental-metrical analysis of spontaneous speech in hypokinetic dysarthria, ataxic dysarthria and foreign accent syndrome

, 2012
The autosegmental-metrical (AM) framework represents an established methodology for intonational analysis in unimpaired speaker populations but has found little application in describing intonation in motor speech disorders (MSDs).
Lowit, Anja, Anja Kuschmann, Anja Lowit, Kuschmann, Anja   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Lived Experiences of Deep Brain Stimulation in Parkinson’s Disease: An Interpretative Phenomenological Analysis

Parkinson's Disease, 2019
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for Parkinson’s disease (PD). In this study, we used an interpretative phenomenological analysis to explore how 10 male people with PD experienced life after STN-DBS ...
Suzette Shahmoon, Jonathan A. Smith, Marjan Jahanshahi   +2 more
doaj   +1 more source

Electrophysiological biomarkers in genetic movement disorders

, 2008
BACKGROUND. Neurodegenerative diseases are diseases of the nervous system with progressive course leading to death. Treatment remains symptomatic. Development of neuroprotective agents has been hampered for various reasons. This includes the inability of
Schneider, K.S.A.I.M
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation [PDF]

, 2012
BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O ...
Laucht, Manfred (Prof. Dr.), Rellum Thomas, Thomas Rellum, Resch, Franz, Stephan Bender, Brandeis, Daniel, Banaschewski, Tobias, Laucht Manfred, Bender, Stephan, Rietschel, Marcella, Jennen-Steinmetz, Christine, Freitag, Christine M., Treutlein, Jens, Jens Treutlein, Rellum, Thomas, Daniel Brandeis, Brandeis Daniel, Tobias Banaschewski, Jennen-Steinmetz Christine, Christine Freitag, Bender Stephan, Banaschewski Tobias, Manfred Laucht, Freitag, Christine, Franz Resch, Rietschel Marcella, Marcella Rietschel, Resch Franz, Christine Jennen-Steinmetz, Laucht, Manfred, Treutlein Jens, Freitag Christine   +31 more
core   +1 more source