Results 51 to 60 of about 1,199,901 (299)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Sustainability of a Given Ten-Week Motor Skills Training Program for Children with Developmental Coordination Disorder

Sports, 2022
The aim of this research was to determine the sustainability of a given ten-week motor skills training program for children with developmental coordination disorder (DCD).
Orifjon Saidmamatov, Ko’palov Sanjarbek, Olga Vasconcelos, Paula Rodrigues   +3 more
doaj   +1 more source

Incremental embodied chaotic exploration of self-organized motor behaviors with proprioceptor adaptation [PDF]

, 2015
This paper presents a general and fully dynamic embodied artificial neural system, which incrementally explores and learns motor behaviors through an integrated combination of chaotic search and reflex learning.
Aida, Akazawa, Asai, Asai, Barlas, Bronsing, Cohen, Conway, Davis, Davis, Dietz, Doya, Eiben, Ekeberg, Fernando, Fitzhugh, Freeman, Goulding, Grillner, Guevara, Hanson, Hill, Hodgkin, Hoerzer, Jean-Xavier, Johnson, Kinjo, Kuniyoshi, Kuniyoshi, Legenstein, Marques, McGregor, Nagumo, Nishimura, Ohgi, Pearson, Pearson, Pelikan, Petersson, Pfeifer, Pfeifer, Pitti, Prochazka, Rapp, Riley, Rosenstein, Schouenberg, Shim, Shim, Shim, Shim, Skarda, Smith, Steingrube, Terman, Turrigiano, Turrigiano, Wheeler, Wolf, Wolpaw, Wolpaw, Wright   +61 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Disengagement of motor cortex from movement control during long-term learning. [PDF]

, 2019
Motor learning involves reorganization of the primary motor cortex (M1). However, it remains unclear how the involvement of M1 in movement control changes during long-term learning.
Aguilar, Karina, Dahlen, Jeffrey E, Hu, Yvonne Yuling, Hwang, Eun Jung, Komiyama, Takaki, Mitani, Akinori, Mukundan, Madan, Yu, Bin   +7 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Assessing Saccadic Eye Movements With Head-Mounted Display Virtual Reality Technology

Frontiers in Psychiatry, 2020
As our society is ageing globally, neurodegenerative disorders are becoming a relevant issue. Assessment of saccadic eye movement could provide objective values to help to understand the symptoms of disorders.
Yu Imaoka, Andri Flury, Eling D. de Bruin, Eling D. de Bruin   +3 more
doaj   +1 more source

Optimal Schedules in Multitask Motor Learning [PDF]

, 2016
Although scheduling multiple tasks in motor learning to maximize long-term retention of performance is of great practical importance in sports training and motor rehabilitation after brain injury, it is unclear how to do so.
Kim, Sung Shin, Lee, Jeong Yoon, Oh, Youngmin, Scheidt, Robert A., Schweighofer, Nicolas   +4 more
core   +1 more source

The Effect of self-controlled practice on forearm passing, motivation, and affect in women’s volleyball players

, 2011
Motor learning research has suggested that self-controlled practice (or “autonomy”) leads to more effective learning of motor tasks. Debate continues, however, as to why.
Rydberg, Nels
core   +1 more source