Results 51 to 60 of about 1,209,275 (350)

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

Learning sequential motor tasks [PDF]

2013 IEEE International Conference on Robotics and Automation, 2013
Many real robot applications require the sequential use of multiple distinct motor primitives. This requirement implies the need to learn the individual primitives as well as a strategy to select the primitives sequentially. Such hierarchical learning problems are commonly either treated as one complex monolithic problem which is hard to learn, or as ...
Daniel, C., Neumann, G., Kroemer, O., Peters, J.   +3 more
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Sustainability of a Given Ten-Week Motor Skills Training Program for Children with Developmental Coordination Disorder

Sports, 2022
The aim of this research was to determine the sustainability of a given ten-week motor skills training program for children with developmental coordination disorder (DCD).
Orifjon Saidmamatov, Ko’palov Sanjarbek, Olga Vasconcelos, Paula Rodrigues   +3 more
doaj   +1 more source

Prefrontal involvement in imitation learning of hand actions : effects of practice and expertise. [PDF]

, 2007
In this event-related fMRI study, we demonstrate the effects of a single session of practising configural hand actions (guitar chords) on cortical activations during observation, motor preparation, and imitative execution.
Buccino, Giovanni, Canessa, Nicola, Eickhoff, Simon B., Fink, Gereon R., Freund, Hans-Joachim, Rizzolatti, Giacomo, Shah, N. Jon, Vogt, Stefan, Wohlschläger, Afra M., Zilles, Karl   +9 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Disengagement of motor cortex from movement control during long-term learning. [PDF]

, 2019
Motor learning involves reorganization of the primary motor cortex (M1). However, it remains unclear how the involvement of M1 in movement control changes during long-term learning.
Aguilar, Karina, Dahlen, Jeffrey E, Hu, Yvonne Yuling, Hwang, Eun Jung, Komiyama, Takaki, Mitani, Akinori, Mukundan, Madan, Yu, Bin   +7 more
core   +1 more source

The Effect of self-controlled practice on forearm passing, motivation, and affect in women’s volleyball players

, 2011
Motor learning research has suggested that self-controlled practice (or “autonomy”) leads to more effective learning of motor tasks. Debate continues, however, as to why.
Rydberg, Nels
core   +1 more source