Results 131 to 140 of about 5,650,462 (303)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The association between motor coordination impairment and altered functional connectivity among autistic children

Frontiers in Pediatrics
BackgroundMotor coordination impairment among children with autism spectrum disorder (ASD) has recently gained increasing attention. However, the relationship between functional connectivity (FC) alterations and motor coordination impairment among ASD ...
Muqing Cao, Chengkai Jin, Jin Jing
doaj   +1 more source

Detailed statement of motor vehicle registrations (in units)

, 2001
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Abnormal EEG Spectral Power and Coherence Measures During Pre-Motor Stage in Amyotrophic Lateral Sclerosis

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder characterized by progressive motor decline. Studies of electroencephalographic (EEG) activity during rest and motor execution have captured network changes in ALS.
Saroj Bista, Amina Coffey, Matthew Mitchell, Antonio Fasano, Stefan Dukic, Teresa Buxo, Eileen Giglia, Mark Heverin, Muthuraman Muthuraman, Richard G. Carson, Madeleine Lowery, Lara McManus, Orla Hardiman, Bahman Nasseroleslami   +13 more
doaj   +1 more source

Detailed statement of motor vehicle registrations (in units)

, 2006
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network

Neurobiology of Disease
Mounting evidence suggests that elevated beta oscillatory activity in the basal ganglia thalamocortical (BGTC) network is associated with the cardinal motor signs in people with Parkinson's disease (PD).
Eesha Bharti, Adele L. DeNicola, Ying Yu, Ajay K. Verma, David Schneck, Biswaranjan Mohanty, Mark Fiecas, Hongyu Yao, Jing Wang, Luke A. Johnson, Jerrold L. Vitek   +10 more
doaj   +1 more source

Summary statement of motor vehicle registrations (in dollars)

, 2000
Annual; Description based on: 2000; title from caption (viewed Aug.

core