Results 121 to 130 of about 1,014,438 (298)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Learning recurrent representations for hierarchical behavior modeling [PDF]
, 2016 We propose a framework for detecting action patterns from motion sequences and modeling the sensory-motor relationship of animals, using a generative recurrent neural network.
Branson, Kristin +3 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Analysis of Time-Dependent Brain Network on Active and MI Tasks for Chronic Stroke Patients.
PLoS ONE, 2015 Several researchers have analyzed brain activities by investigating brain networks. However, there is a lack of the research on the temporal characteristics of the brain network during a stroke by EEG and the comparative studies between motor execution ...
Da-Hye Kim +6 more
doaj +1 more source
Microscopic basis for pattern formation and anomalous transport in two-dimensional active gels
, 2010 Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network.
Briels, W. J. +2 more
core +1 more source
Artificial neural networks, motor programs and motor learning
, 2012 published_or_final_version ; Physiology ; Doctoral ; Doctor of ...
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
To develop an efficient variable speed compressor motor system [PDF]
, 2007 This research presents a proposed new method of improving the energy efficiency of a Variable Speed Drive (VSD) for induction motors. The principles of VSD are reviewed with emphasis on the efficiency and power losses associated with the operation of the
Mohd. Yatim, Abdul Halim +1 more
core
Network connectivity of motor control in the ageing brain
NeuroImage: Clinical, 2018 Older individuals typically display stronger regional brain activity than younger subjects during motor performance. However, knowledge regarding age-related changes of motor network interactions between brain regions remains scarce. We here investigated the impact of ageing on the interaction of cortical areas during movement selection and initiation ...
Michely, J +6 more
openaire +6 more sources