Results 151 to 160 of about 2,351,931 (407)

Provision, cough efficacy and treatment satisfaction of mechanical insufflation-exsufflation in a large multicenter cohort of patients with amyotrophic lateral sclerosis

Scientific Reports
In patients with amyotrophic lateral sclerosis (ALS), mechanical insufflation-exsufflation (MI-E) addresses cough deficiency to achieve major therapeutic goals: improving costal muscle and joint function, reducing atelectasis through insufflation, and ...
André Maier, Dagmar Kettemann, Ute Weyen, Torsten Grehl, Peter Caspar Schulte, Robert Steinbach, Annekathrin Rödiger, Patrick Weydt, Susanne Petri, Joachim Wolf, Julian Grosskreutz, Jan Christoph Koch, Jochen H. Weishaupt, Simone Rosseau, Jenny Norden, Peter Körtvélyessy, Birgit Koch, Teresa Holm, Barbara Hildebrandt, Peggy Schumann, Bertram Walter, Alessio Riitano, Christoph Münch, Thomas Meyer, Susanne Spittel   +24 more
doaj   +1 more source

Prefrontal involvement in imitation learning of hand actions : effects of practice and expertise. [PDF]

, 2007
In this event-related fMRI study, we demonstrate the effects of a single session of practising configural hand actions (guitar chords) on cortical activations during observation, motor preparation, and imitative execution.
Buccino, Giovanni, Canessa, Nicola, Eickhoff, Simon B., Fink, Gereon R., Freund, Hans-Joachim, Rizzolatti, Giacomo, Shah, N. Jon, Vogt, Stefan, Wohlschläger, Afra M., Zilles, Karl   +9 more
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Modulation of cortical motor outputs by the symbolic meaning of visual stimuli. [PDF]

, 2010
The observation of an action modulates motor cortical outputs in specific ways, in part through mediation of the mirror neuron system. Sometimes we infer a meaning to an observed action based on integration of the actual percept with memories.
Aziz-Zadeh, Aziz-Zadeh, Aziz-Zadeh, Calvo-Merino, Casile, Catmur, Celnik, Cross, Fadiga, Fadiga, Fadiga, Fecteau, Ferrari, Galati, Gazzola, Kilner, Kilner, Lestou, Maeda, Pascual-Leone, Pineda, Press, Reithler, Rizzolatti, Rizzolatti, Stanley, Tai, Turella, Umiltà   +28 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

UROLOGICAL STUDIES ON PATIENTS WITH TRAUMATIC SPINAL CORD INJURY Part 1 : Clinical Observations and Neurological Investigations [PDF]

, 1963
Examinationso f various neurologicalt ests and observations o f the ways of urination were performed in a total of 55 patients with traumatic spinal cord injury.
伊藤, 順勉
core  

Large-scale Spatiotemporal Spike Patterning Consistent with Wave Propagation in Motor Cortex [PDF]

, 2015
Aggregate signals in cortex are known to be spatiotemporally organized as propagating waves across the cortical surface, but it remains unclear whether the same is true for spiking activity in individual neurons.
Best, Matthew D., Brown, Kevin A., Coleman, Todd P., Hatsopoulos, Nicholas G., Kim, Sanggyun, Suminski, Aaron J., Takahashi, Kazutaka   +6 more
core   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source