Results 41 to 50 of about 443,128 (313)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles

Biology Open, 2013
Summary Amyotrophic Lateral Sclerosis (ALS) is a motor neuron degenerative disease characterized by a progressive, and ultimately fatal, muscle paralysis. The human VAMP-Associated Protein B (hVAPB) is the causative gene of ALS type 8.
Mario Sanhueza, Luigi Zechini, Trudy Gillespie, Giuseppa Pennetta   +3 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

cDNA that encodes active agrin [PDF]

, 1992
Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments,
Bolander, Bourgeois, Campanelli, Chi, Dahm, Devereux, Dohrmann, Elliott, Fallon, Feinberg, Gluzman, Godfrey, Godfrey, Godfrey, Gubler, Henikoff, Hunter, Hunter, Kidd, Knust, Lankat-Buttgereit, Luthman, Magill-Solc, Magill-Solc, McMahan, Nitkin, Pearson, Pikkarainen, Pikkarainen, Ranscht, Reist, Rothberg, Ruegg, Rupp, Sambrook, Sanger, Shimasaki, Tabor, Tsim, von Heijne, Wallace, Wallace, Wilson   +42 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Spermidine treatment: induction of autophagy but also apoptosis?

Molecular Brain
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis.
Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan, Angela S. Laird   +7 more
doaj   +1 more source

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

Cell Reports, 2015
Neurodegenerative phenotypes reflect complex, time-dependent molecular processes whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus in neurodegeneration has been on individual genes and pathways.
Burcin Ikiz, Mariano J. Alvarez, Diane B. Ré, Virginia Le Verche, Kristin Politi, Francesco Lotti, Sudarshan Phani, Radhika Pradhan, Changhao Yu, Gist F. Croft, Arnaud Jacquier, Christopher E. Henderson, Andrea Califano, Serge Przedborski   +13 more
doaj   +1 more source

Use and subjective experience of the impact of motor-assisted movement exercisers in people with amyotrophic lateral sclerosis: a multicenter observational study

Scientific Reports, 2022
Motor-assisted movement exercisers (MME) are devices that assist with physical therapy in domestic settings for people living with ALS. This observational cross-sectional study assesses the subjective experience of the therapy and analyzes users ...
André Maier, Marcel Gaudlitz, Torsten Grehl, Ute Weyen, Robert Steinbach, Julian Grosskreutz, Annekathrin Rödiger, Jan Christoph Koch, Teresa Lengenfeld, Patrick Weydt, René Günther, Joachim Wolf, Petra Baum, Moritz Metelmann, Johannes Dorst, Albert C. Ludolph, Dagmar Kettemann, Jenny Norden, Ruhan Yasemin Koc, Bertram Walter, Barbara Hildebrandt, Christoph Münch, Thomas Meyer, Susanne Spittel   +23 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Ca2+-activated K+ channels modulate microglia affecting motor neuron survivalin hSOD1G93A mice [PDF]

, 2018
Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration ...
Antonangeli, Fabrizio, Carbonari, Laura, Cocozza, Germana, D'Alessandro, Giuseppina, di Castro, Maria Amalia, Garofalo, Stefano, Grassi, Francesca, Grimaldi, Alfonso, Limatola, Cristina, Madonna, Michele, Mainiero, Fabrizio, Porzia, Alessandra, Santoni, Angela, Wulff, Heike   +13 more
core   +2 more sources