Results 41 to 50 of about 213,623 (266)

Cyclin F can alter the turnover of TDP-43

Neurobiology of Disease
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43.
Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee   +12 more
doaj   +1 more source

Motor Neuron Susceptibility in ALS/FTD

Frontiers in Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord.
Audrey M. G. Ragagnin, Sina Shadfar, Marta Vidal, Md Shafi Jamali, Julie D. Atkin, Julie D. Atkin   +5 more
doaj   +1 more source

The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration

Frontiers in Cellular Neuroscience, 2022
Damage to DNA is generally considered to be a harmful process associated with aging and aging-related disorders such as neurodegenerative diseases that involve the selective death of specific groups of neurons.
Anna Konopka, Julie D. Atkin, Julie D. Atkin   +2 more
doaj   +1 more source

Diagnosing motor neurone disease [PDF]

BMJ, 1996
Advanced motor neurone disease is easily recognised. Progressively worsening dysphagia and dysarthria, and widespread wasting and weakness of the limbs with hyperactive reflexes in a corresponding wasted myotome in the absence of other neurological signs are unmistakable features.
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

User expectations and experiences of an assistive robotic arm in amyotrophic lateral sclerosis: a multicenter observational study

Neurological Research and Practice
Objective Robotic arms are innovative assistive devices for ALS patients with progressive motor deficits of arms and hands. The objective was to explore the patients´ expectations towards a robotic arm system and to assess the actual experiences after ...
Susanne Spittel, Thomas Meyer, Ute Weyen, Torsten Grehl, Patrick Weydt, Robert Steinbach, Susanne Petri, Petra Baum, Moritz Metelmann, Anne-Dorte Sperfeld, Dagmar Kettemann, Jenny Norden, Annekathrin Rödiger, Benjamin Ilse, Julian Grosskreutz, Barbara Hildebrandt, Bertram Walter, Christoph Münch, André Maier   +18 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement

Molecular Neurodegeneration
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis.
Natalie Grima, Andrew N. Smith, Claire E. Shepherd, Lyndal Henden, Thiri Zaw, Luke Carroll, Dominic B. Rowe, Matthew C. Kiernan, Ian P. Blair, Kelly L. Williams   +9 more
doaj   +1 more source

Degenerative and regenerative mechanisms governing spinal cord injury

Neurobiology of Disease, 2004
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally accepted treatment. The functional decline following SCI is contributed to both direct mechanical injury and secondary pathophysiological mechanisms that are
Christos Profyris, Surindar S Cheema, DaWei Zang, Michael F Azari, Kristy Boyle, Steven Petratos   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source