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Middle motor neurone disease

Irish Journal of Medical Science, 1964
(1) A ten year old girl was admitted to hospital suffering from upper motor paralysis. (2) Consideration of the signs, symptoms and progress of the case indicates that this was a mild but extensive case of posterior poliomyelitis, restricted to the middle motor neurone, with which the upper motor neurone synapses.
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Neurons but Motor Neurons in Motor Neuron disease

2014
The occurrence of motor neuron death is the milestone of amyotrophic lateral sclerosis (ALS). Therefore, morphological analysis along decades focussed on motor neuron loss as the sole marker to score disease severity. Recently, non autonomous cell death took a prominent role to explain the need for additional cell types to induce motor neuron ...
Fornai, Francesco   +8 more
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Motor neurone disease

InnovAiT: Education and inspiration for general practice, 2020
Motor neurone disease describes a group of rare, fatal, neurodegenerative disorders. They are devastating conditions that cause the loss of upper and/or lower motor neurones, leading to a variety of progressive neurological symptoms that can develop over months to years.
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Motor Neuron Diseases

2014
The loss of afferent and efferent signal transduction following traumatic peripheral nerve injury has immediate and long-term effects on target organs (e.g., muscles and sensory receptors) as well as somatosensory and motor brain areas. The goal of surgical peripheral nerve repair is to mitigate these negative outcomes by restoring the continuity of ...
Wolfgang N. Löscher, Eva L. Feldman
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Motor Neuron Disease

1999
Motor neuron disease (MND) refers to the group of degenerative disorders characterized by progressive weakness and atrophy of skeletal muscle due to the selective dysfunction and degeneration of upper and/or lower motor neurons. In adults, the most common of these disorders is amyotrophic lateral sclerosis (ALS, i.e., Lou Gehrig’s disease), which ...
Bruce A. Rabin, David R. Borchelt
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Motor neuron disease

2018
Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
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Motor neurone disease

Independent Nurse, 2008
Aetiology and diagnosis plus support and palliative care options
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Motor Neuron Disease

1985
The most severe denervating disorders are those due to degeneration and loss of motor nerve cells. Poliomyelitis is an example of acute anterior horn.cell disease attributable to the cytopathic effects of the virus, but is unlikely to require diagnostic muscle biopsy.
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Motor neurone disease

2015
In this chapter, the following ten key events in motor neurone disease, also known as amyotrophic lateral sclerosis (ALS), are considered: the first description of ALS by Cruveilhier; discovery of the first SOD1 mutation; use of the ALSFRS (functional rating scale) for determining therapeutic trial outcomes; the contentious issue of establishing the ...
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Motor neurone disease.

Essays in biochemistry, 1994
Motor neurone disease, or amyotrophic lateral sclerosis, is a serious progressive neurological disorder, characterized by loss of UMN and LMN. Pathological features include characteristic intracytoplasmic MN inclusion bodies and appearances on ubiquitin staining.
A, Goonetilleke   +2 more
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