Results 71 to 80 of about 423,991 (315)

Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease

Neurobiology of Disease
We previously identified microbial shifts prior to the onset of motor and neurological symptoms within a mouse model of the fatal neurodegenerative disease Machado-Joseph disease (MJD).
Vasilisa Zvyagina, Andrea Kuriakose, Ignacio Simó, Julia Y. Kam, Prapti Chakraborty, Katherine J. Robinson, Anastasiya Potapenko, Maxinne Watchon, Ian T. Paulsen, Hasinika K.A.H. Gamage, Angela S. Laird   +10 more
doaj   +1 more source

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity

Frontiers in Neuroscience, 2020
Despite the identification of molecular mechanisms associated with pain persistence, no significant therapeutic improvements have been made. Advances in the understanding of the molecular mechanisms that induce pain hypersensitivity will allow the ...
Ananda Staats Pires, Ananda Staats Pires, Vanessa X. Tan, Benjamin Heng, Gilles J. Guillemin, Alexandra Latini   +5 more
doaj   +1 more source

Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion

Scientific Reports, 2021
The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a population of glutamatergic neurons, termed Hb9 interneurons, contributes to locomotor rhythmogenesis.
Lina M. Koronfel, Kevin C. Kanning, Angelita Alcos, Christopher E. Henderson, Robert M. Brownstone   +4 more
doaj   +1 more source

Motor Neuron Disease

Springer London, 2011
This datasheet on motor neuron disease covers Identity, Hosts/Species Affected.
H. E. Tallawy
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dissection and Whole-Mount Immunofluorescent Staining of Mouse Hind Paw Muscles for Neuromuscular Junction Analysis

Bio-Protocol
The neuromuscular junction (NMJ) is a peripheral synaptic connection between a lower motor neuron and skeletal muscle fibre that enables muscle contraction in response to neuronal stimulation.
Rebecca Simkin, Elena Rhymes, Qiuhan Lang, Nicol Birsa, James Sleigh   +4 more
doaj   +1 more source

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

EMBO Molecular Medicine, 2013
Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP‐43 and FUS/TLS, and SMN, respectively.
Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue, Koji Yamanaka   +11 more
doaj   +1 more source

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

Brain : a journal of neurology, 2012
In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration with neuroprotective pharmacological agents; early diagnosis and treatment are thus essential.
K. Fisher, B. Zaaimi, T. Williams, S. Baker, M. Baker   +4 more
semanticscholar   +1 more source

Imperial strategy of cancer cells through mitochondrial transfer

Molecular Oncology, EarlyView.
Cangkrama et al. demonstrated that cancer cells donate their mitochondria to fibroblasts through mitochondrial transfer, reprogramming them into ‘MitoCAF’. Likewise, our group has identified mitochondrial transfer from cancer cells to tumor infiltrating lymphocytes, resulting in mitochondrial ‘hijack’ and impaired antitumor immunity.
Takamasa Ishino, Yosuke Togashi
wiley   +1 more source

Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease

Journal of Neuroscience, 2012
A growing body of research indicates that amyotrophic lateral sclerosis (ALS) patients and mouse models of ALS exhibit metabolic dysfunction. A subpopulation of ALS patients possesses higher levels of resting energy expenditure and lower fat-free mass ...
Mary Ann Lim, M. Selak, Zhongmin Xiang, Dimitri Krainc, Rachael L. Neve, Brian C. Kraemer, Jennifer L. Watts, Robert G Kalb   +7 more
semanticscholar   +1 more source