Results 51 to 60 of about 6,008,570 (306)
The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration
Frontiers in Cellular Neuroscience, 2022 Damage to DNA is generally considered to be a harmful process associated with aging and aging-related disorders such as neurodegenerative diseases that involve the selective death of specific groups of neurons.
Anna Konopka +2 more
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The Neurologist, 2009 The existence of a large number of neurological diseases in which the motor neuron is the principal site of pathology suggests that these cells and their neuronal networks have a specific set of vulnerabilities. Recent research, largely based on relatively rare genetic forms of motor neuron disease, indicates that these cells are vulnerable to defects ...
openaire +4 more sources
Advances in motor neurone disease [PDF]
Journal of the Royal Society of Medicine, 2014 Summary Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of adult-onset neurodegenerative disorders. The last decade has seen major improvements in patient care, but also rapid scientific advances, so that rational therapies based on ...
Bäumer, D, Talbot, K, Turner, M
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Spermidine treatment: induction of autophagy but also apoptosis?
Molecular BrainMachado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis.
Maxinne Watchon +7 more
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Management of motor neurone disease [PDF]
Postgraduate Medical Journal, 2002 Abstract Motor neurone disease is a progressive neurodegenerative disorder leading to severe disability and death. It is clinically characterised by mixed upper and lower motor neurone involvement affecting bulbar, limb, and respiratory musculature.
R S, Howard, R W, Orrell
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Amyotrophic lateral sclerosis – a motor neuron disease. Case report [PDF]
, 2015 Amyotrophic lateral sclerosis, also known as Charcot’s disease and motor neuron disease, is a progressive neurodegenerative disease that causes muscle weakness, paralysis, and ultimately, respiratory failure.
Maja Rubinowicz-Zasada +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cyclin F can alter the turnover of TDP-43
Neurobiology of DiseasePreviously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43.
Stephanie L. Rayner +12 more
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Intraperitoneal Injection of Neonatal Mice
Bio-Protocol, 2023 Administration of substances into neonatal mice is required for early treatment with pre-clinical therapeutics, delivery of recombination-inducing substances, and dosing with viruses or toxins, amongst other things.
Amanda Pocratsky, James Sleigh
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