Results 51 to 60 of about 2,514,411 (397)

Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain. [PDF]

, 2020
Physical exercise promotes motor skill learning in normal individuals and those with neurological disorders but its mechanism of action is unclear. We find that one week of voluntary wheel running enhances the acquisition of motor skills in normal adult ...
Li, Hui-Quan, Spitzer, Nicholas C
core  

Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]

, 2018
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying, Chen, Xing, Hamilton, Thomas A., Herjan, Tomasz, Kokiko-Cochran, Olga N., Lamb, Bruce, Lee, Yu-Shang, Li, Xiao, Lin, Ching-Yi, Sun, Kevin, Zhou, Gao   +10 more
core   +1 more source

Specialized coding of sensory, motor, and cognitive variables in VTA dopamine neurons

Nature, 2019
There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the distance to reward3, movements4–9 and behavioural choices10,11. An important question
B. Engelhard, Joel Finkelstein, Julia Cox, Weston Fleming, H. Jang, Sharon Ornelas, S. A. Koay, S. Thiberge, N. Daw, D. Tank, Ilana B. Witten   +10 more
semanticscholar   +1 more source

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.

PLoS Genetics, 2015
Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs.
Namhee Kim, Chungoo Park, Yongsu Jeong, Mi-Ryoung Song   +3 more
doaj   +1 more source

Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]

, 2019
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi, Jin, Xiaoming, Qian, Jun, Wu, Wei, Xiong, Wenhui, Xu, Xiao-Ming   +5 more
core   +1 more source

Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector [PDF]

, 2018
Human pluripotent stem cells (PSCs) are widely used for in vitro disease modeling. One of the challenges in the field is represented by the ability of converting human PSCs into specific disease-relevant cell types.
De Santis, Riccardo, de Turris, Valeria, Di Angelantonio, Silvia, Garone, Maria Giovanna, Pagani, Francesca, Rosa, Alessandro   +5 more
core   +2 more sources

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

Stem Cells International, 2016
The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet.
Ji-Yon Kim, So-Youn Woo, Young Bin Hong, Heesun Choi, Jisoo Kim, Hyunjung Choi, Inhee Mook-Jung, Nina Ha, Jangbeen Kyung, Soo Kyung Koo, Sung-Chul Jung, Byung-Ok Choi   +11 more
doaj   +1 more source

Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors

Nature Communications, 2023
Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar
Meike E. van der Heijden, Alejandro G. Rey Hipolito, Linda H. Kim, Dominic J. Kizek, Ross M. Perez, Tao Lin, Roy V. Sillitoe   +6 more
doaj   +1 more source

Recognizing Speech in a Novel Accent: The Motor Theory of Speech Perception Reframed [PDF]

, 2013
The motor theory of speech perception holds that we perceive the speech of another in terms of a motor representation of that speech. However, when we have learned to recognize a foreign accent, it seems plausible that recognition of a word rarely ...
A Basirat, A Francis, AH Fagg, AJ Lotto, AJ Lotto, AJ Viterbi, AL Francis, AM Barrett, AM Liberman, AM Liberman, AN Meltzoff, AR Bradlow, AR Luria, B Galantucci, B Lindblom, BJ Kröger, C Best, Clément Moulin-Frier, D Norris, DH Klatt, DL Hintzman, E Kohler, E Oztop, E Oztop, ET Jaynes, F Eisner, FH Guenther, G Buccino, G Hickok, G Hickok, G Rizzolatti, G Rizzolatti, G Rizzolatti, GD Brown, IP Association, J Pierrehumbert, J-L Schwartz, JB Bonaiuto, JB Bonaiuto, JI Skipper, JP Rauschecker, JP Rauschecker, L Goldstein, LG Ungerleider, LR Bahl, LR Rabiner, M Adda-Decker, M Sato, M Studdert-Kennedy, M Wilson, MA Arbib, MA Arbib, MA Arbib, MA Arbib, MA Arbib, MA Goodale, MA Umiltà, Michael A. Arbib, PF Ferrari, PF Ferrari, PF MacNeilage, PF MacNeilage, PK Kuhl, RL Goldstone, S Grossberg, S Hawkins, S Moineau, SD Goldinger, V Gallese, V Wassenhove van   +69 more
core   +4 more sources

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

Journal of Neuroscience, 2016
Spinal muscular atrophy (SMA) is a neurodegenerative disease primarily affecting spinal motor neurons. It is caused by reduced levels of the survival of motor neuron (SMN) protein, which plays an essential role in the biogenesis of spliceosomal small ...
C. Fallini, Paul G. Donlin-Asp, Jeremy P. Rouanet, G. Bassell, W. Rossoll   +4 more
semanticscholar   +1 more source