Results 51 to 60 of about 552,175 (353)

Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain. [PDF]

open access: yes, 2020
Physical exercise promotes motor skill learning in normal individuals and those with neurological disorders but its mechanism of action is unclear. We find that one week of voluntary wheel running enhances the acquisition of motor skills in normal adult ...
Li, Hui-Quan, Spitzer, Nicholas C
core  

Comparing Offline Decoding Performance in Physiologically Defined Neuronal Classes [PDF]

open access: yes, 2016
Objective: Recently, several studies have documented the presence of a bimodal distribution of spike waveform widths in primary motor cortex. Although narrow and wide spiking neurons, corresponding to the two modes of the distribution, exhibit different ...
Best, Matthew D.   +5 more
core   +2 more sources

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.

open access: yesPLoS Genetics, 2015
Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs.
Namhee Kim   +3 more
doaj   +1 more source

Modulation of motor behavior by the mesencephalic locomotor region

open access: yesCell Reports, 2021
Summary: The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), and ...
Daniel Dautan   +5 more
doaj   +1 more source

Motor Neurone Disease [PDF]

open access: yesPostgraduate Medical Journal, 1962
THE story of motor neurone disease goes back more than a hundred years, to the latter half of the igth century, and the days of the great clinical neurologists of France. Of the many famous names linked to this story three are pre-eminent: Charcot-physician and neuropathologist, and great teacher, who became even more renowned for his studies of ...
openaire   +3 more sources

Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]

open access: yes, 2019
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi   +5 more
core   +1 more source

Heavy metals in locus ceruleus and motor neurons in motor neuron disease [PDF]

open access: yesActa Neuropathologica Communications, 2013
The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to
Roger Pamphlett, Stephen Kum Jew
openaire   +3 more sources

Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]

open access: yes, 2018
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying   +10 more
core   +1 more source

Recognizing Speech in a Novel Accent: The Motor Theory of Speech Perception Reframed [PDF]

open access: yes, 2013
The motor theory of speech perception holds that we perceive the speech of another in terms of a motor representation of that speech. However, when we have learned to recognize a foreign accent, it seems plausible that recognition of a word rarely ...
A Basirat   +69 more
core   +4 more sources

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

open access: yesStem Cells International, 2016
The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet.
Ji-Yon Kim   +11 more
doaj   +1 more source

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