Results 61 to 70 of about 536,263 (355)

State Variables of the Arm May Be Encoded by Single Neuron Activity in the Monkey Motor Cortex [PDF]

, 2016
Revealing the type of information encoded by neurons activity in the motor cortex is essential not only for understanding the mechanism of motion control but also for developing a brain-machine interface.
Eizo Miyashita, Yutaka Sakaguchi
core   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity

Cell Reports, 2017
Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output.
Sarah Melzer, Mariana Gil, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer   +5 more
doaj  

Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice

BMC Neuroscience, 2011
Background The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system.
Turnbull John, Peterson Randy, Ma Xiaoxing   +2 more
doaj   +1 more source

Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control [PDF]

, 2019
The spinal cord contains a diverse array of interneurons that govern motor output. Traditionally, models of spinal circuits have emphasized the role of inhibition in enforcing reciprocal alternation between left and right sides or flexors and extensors ...
Bagnall, Martha W, Callahan, Rebecca A, Higashijima, Shin-Ichi, Kimura, Yukiko, Roberts, Richard, Sengupta, Mohini   +5 more
core   +1 more source

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]

, 2013
Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E, Cleveland, Don W, Fukaya, Masahiro, Kang, Shin H, Li, Ying, Lorenzini, Ileana, Ostrow, Lyle W, Rothstein, Jeffrey D   +7 more
core   +2 more sources

Motor Neurons and the Sense of Place [PDF]

Neuron, 2011
Seventy years ago George Romanes began to document the anatomical organization of the spinal motor system, uncovering a multilayered topographic plan that links the clustering and settling position of motor neurons to the spatial arrangement and biomechanical features of limb muscles.
John S. Kelly, Thomas M. Jessell, Gülşen Sürmeli   +2 more
openaire   +3 more sources

The lower motor neuron homunculus

Brain, 2022
Penfield’s motor homunculus anthropomorphizes the cerebral level of motor control, the upper motor neuron. However, it leaves the cranial and spinal motor neurons unrepresented. Here Ravits and Stack redress the imbalance by presenting a lower motor neuron homunculus.
Ravits, John, Stack, Julia
openaire   +4 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source