Results 281 to 290 of about 722,567 (342)

A mouse model of CHCHD10 p.R15L familial ALS presents mild, age-related motor neuron degeneration without protein instability or mitochondrial dysfunction

JoonHyung Park, Анна Степанова, Jalia Dash, Nneka Southwell, Dazhi Zhao, Csaba Konràd, Paridhi Taygi, Justin Y Kwan, Neil A. Shneider, George Z. Mentis, Giovanni Manfredi, Hibiki Kawamata   +11 more
openalex   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances El bloqueo de las proteínas cinasas activadas por mitógenos mejora las alteraciones motoras inducidas por el lipopolisacárido en íleon

, 2012
Sergio Gonzálo, Laura Grasa, Ligia Verónica Hernández, María Pilar Arruebo, Miguel Ángel Plaza, María Divina Murillo   +5 more
openalex   +1 more source

[Cytoplasmic motor proteins].

Postepy biochemii, 1994
openaire   +1 more source

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Rotary protein motors

Trends in Cell Biology, 2003
Three protein motors have been unambiguously identified as rotary engines: the bacterial flagellar motor and the two motors that constitute ATP synthase (F(0)F(1) ATPase). Of these, the bacterial flagellar motor and F(0) motors derive their energy from a transmembrane ion-motive force, whereas the F(1) motor is driven by ATP hydrolysis. Here, we review
George, Oster, Hongyun, Wang
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Yeast motor proteins

Folia Microbiologica, 1995
Yeast accomplish a variety of intracellular motile events with the aid of mechanochemical enzymes known as motor proteins. This review covers the current state of knowledge on myosins, kinesins, dyneins, dynamins and SMC proteins present in yeast cells, and the most important developments in the study of yeast mitosis.
E, Streiblová, R, Bonaly
openaire   +2 more sources

Motor Proteins and Spermatogenesis

2021
Unlike the intermediate filament- and septin-based cytoskeletons which are apolar structures, the microtubule (MT) and actin cytoskeletons are polarized structures in mammalian cells and tissues including the testis, most notable in Sertoli cells. In the testis, these cytoskeletons that stretch across the epithelium of seminiferous tubules and lay ...
Siwen, Wu, Huitao, Li, Lingling, Wang, Nathan, Mak, Xiaolong, Wu, Renshan, Ge, Fei, Sun, C Yan, Cheng   +7 more
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Motor neurons rely on motor proteins

Trends in Cell Biology, 2004
The importance of active axonal transport to the neuron has been highlighted by the recent discoveries that mutations in microtubule motor proteins result in neurodegenerative diseases. Mutations affecting microtubule motor function have been shown to cause hereditary forms of Charcot-Marie-Tooth disease (type 2A), hereditary spastic paraplegia and ...
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Targeting of Motor Proteins

Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
openaire   +2 more sources