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Motor proteins transporting cargos
The European Physical Journal E, 2005Processive motor proteins such as kinesin and myosin-V are enzymes that use the energy of ATP hydrolysis to travel along polar cytoskeletal filaments. One of the functions of these proteins is the transport of vesicles and protein complexes that are linked to the light chains of the motors. Modeling the light chain by a linear elastic spring, and using
Zeldovich, K. B. +2 more
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Coupling between motor proteins determines dynamic behaviors of motor protein assemblies
Physical Chemistry Chemical Physics, 2010Transport of intracellular cargos by multiple microtubule motor proteins is believed to be a common and significant phenomenon in vivo, yet signatures of the microscopic dynamics of multiple motor systems are only now beginning to be resolved. Understanding these mechanisms largely depends on determining how grouping motors affect their association ...
Jonathan W, Driver +5 more
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Cytoplasmic microtubule-based motor proteins
Current Opinion in Cell Biology, 1993A multitude of microtubule-based motors drives diverse forms of intracellular transport and generates forces for maintaining the dynamic structural organization of cytoplasm. Recent work has illuminated the functions and mechanisms of action of some microtubule motors, and appears to have uncovered unforseen functional interactions between tubulin ...
D A, Skoufias, J M, Scholey
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Microtubule-based motor proteins
Current Opinion in Cell Biology, 1990Virtually all eukaryotes actively transport or position intracellular components (for example, chromosomes or membrane-bounded organelles), and some cells have developed means of moving through aqueous environments or on top of substrates. Such motile processes invob,'ed interactions between cytoskeletal fibers and 'motor' proteins that generate force ...
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The Mitochondrial Protein Import Motor
Biological Chemistry, 2000Mitochondrial proteins are synthesized as precursor proteins in the cytosol and are posttranslationally imported into the organelle. A complex system of translocation machineries recognizes and transports the precursor polypeptide across the mitochondrial membranes.
Strub, Andreas +3 more
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Protein profile, 1996
Progress regarding the kinesins is now being made at a rapid and accelerating rate. The in vivo-functions, and biophysical and enzymatic properties of kinesin itself are being explored at ever increasing levels of detail. The kinesin-related proteins now number several dozen, and although more is known about primary structure than function for most of ...
G S, Bloom, S A, Endow
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Progress regarding the kinesins is now being made at a rapid and accelerating rate. The in vivo-functions, and biophysical and enzymatic properties of kinesin itself are being explored at ever increasing levels of detail. The kinesin-related proteins now number several dozen, and although more is known about primary structure than function for most of ...
G S, Bloom, S A, Endow
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Motor proteins in cell division
Trends in Cell Biology, 1991The movements of eukaryotic cell division depend upon the conversion of chemical energy into mechanical work, which in turn involves the actions of motor proteins, molecular transducers that generate force and motion relative cytoskeletal elements. In animal cells, microtubule-based motor proteins of the mitotic apparatus are involved in segregating ...
K E, Sawin, J M, Scholey
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Mechanisms of motor protein reversal
Current Opinion in Cell Biology, 2001Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and whether kinesins and myosins share ...
T, Hasson, R E, Cheney
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2007
Motor proteins are molecular machines that convert the chemical energy derived from the hydrolysis of ATP into mechanical work used to power cellular motility. In addition to specialized motile cells like muscle fibers and cellular processes like cilia, all eukaryotic cells contain motor proteins (Fig. 1).
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Motor proteins are molecular machines that convert the chemical energy derived from the hydrolysis of ATP into mechanical work used to power cellular motility. In addition to specialized motile cells like muscle fibers and cellular processes like cilia, all eukaryotic cells contain motor proteins (Fig. 1).
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Mutational Analysis of Motor Proteins
Annual Review of Physiology, 1996Mutations in motor proteins, which can arise by design or randomly, provide powerful insights into the normal function of the protein. This review organizes the available data on mutations of members of the myosin, kinesin, and dynein superfamilies of motor proteins.
H L, Sweeney, E L, Holzbaur
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