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Molecular Assembly of Rotary and Linear Motor Proteins.

Accounts of Chemical Research, 2019
Molecular machines are an important and emerging frontier in research encompassing interdisciplinary subjects of chemistry, physics, biology, and nanotechnology. Although there has been major interest in creating synthetic molecular machines, research on
Yi Jia, Junbai Li
semanticscholar   +1 more source

Motor neurons rely on motor proteins

Trends in Cell Biology, 2004
The importance of active axonal transport to the neuron has been highlighted by the recent discoveries that mutations in microtubule motor proteins result in neurodegenerative diseases. Mutations affecting microtubule motor function have been shown to cause hereditary forms of Charcot-Marie-Tooth disease (type 2A), hereditary spastic paraplegia and ...
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Targeting of Motor Proteins

Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Motor proteins transporting cargos

The European Physical Journal E, 2005
Processive motor proteins such as kinesin and myosin-V are enzymes that use the energy of ATP hydrolysis to travel along polar cytoskeletal filaments. One of the functions of these proteins is the transport of vesicles and protein complexes that are linked to the light chains of the motors. Modeling the light chain by a linear elastic spring, and using
Zeldovich, K. B.   +2 more
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Coupling between motor proteins determines dynamic behaviors of motor protein assemblies

Physical Chemistry Chemical Physics, 2010
Transport of intracellular cargos by multiple microtubule motor proteins is believed to be a common and significant phenomenon in vivo, yet signatures of the microscopic dynamics of multiple motor systems are only now beginning to be resolved. Understanding these mechanisms largely depends on determining how grouping motors affect their association ...
Jonathan W, Driver   +5 more
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Cytoplasmic microtubule-based motor proteins

Current Opinion in Cell Biology, 1993
A multitude of microtubule-based motors drives diverse forms of intracellular transport and generates forces for maintaining the dynamic structural organization of cytoplasm. Recent work has illuminated the functions and mechanisms of action of some microtubule motors, and appears to have uncovered unforseen functional interactions between tubulin ...
D A, Skoufias, J M, Scholey
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Microtubule-based motor proteins

Current Opinion in Cell Biology, 1990
Virtually all eukaryotes actively transport or position intracellular components (for example, chromosomes or membrane-bounded organelles), and some cells have developed means of moving through aqueous environments or on top of substrates. Such motile processes invob,'ed interactions between cytoskeletal fibers and 'motor' proteins that generate force ...
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The Mitochondrial Protein Import Motor

Biological Chemistry, 2000
Mitochondrial proteins are synthesized as precursor proteins in the cytosol and are posttranslationally imported into the organelle. A complex system of translocation machineries recognizes and transports the precursor polypeptide across the mitochondrial membranes.
Strub, Andreas   +3 more
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Motor proteins. 1: kinesins.

Protein profile, 1996
Progress regarding the kinesins is now being made at a rapid and accelerating rate. The in vivo-functions, and biophysical and enzymatic properties of kinesin itself are being explored at ever increasing levels of detail. The kinesin-related proteins now number several dozen, and although more is known about primary structure than function for most of ...
G S, Bloom, S A, Endow
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Motor proteins in cell division

Trends in Cell Biology, 1991
The movements of eukaryotic cell division depend upon the conversion of chemical energy into mechanical work, which in turn involves the actions of motor proteins, molecular transducers that generate force and motion relative cytoskeletal elements. In animal cells, microtubule-based motor proteins of the mitotic apparatus are involved in segregating ...
K E, Sawin, J M, Scholey
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