Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Motor Games for Learning Fundamental Motor Skills
Active Initiation Guidelines recommend that children up to age 5 years engage in daily physical activity to develop basic motor skills for health-related fitness. However, many entering kindergarten today have low motor skills and many more are predicted to have lower motor coordination skills tomorrow.
openaire +2 more sources
Effect of a Child-Owned Poultry Intervention Providing Eggs on Nutrition Status and Motor Skills of Young Children in Southern Ethiopia: A Cluster Randomized and Controlled Community Trial [PDF]
, 2022 Anteneh Omer +2 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Excellence of Batik Art: Exploring the Impact of Batik Jumputan on Fine Motor Skills in Early Childhood Education [PDF]
Nur Izzah, Joko Pamungkas
openalex +1 more source
The Sports Game – A Means of Developing Motor Skills in Secondary School. A Study on Strength and Endurance [PDF]
, 2018 Laurenţiu-Gabriel Talaghir +2 more
openalex +1 more source
Association of Physical Education With Improvement of Health-Related Physical Fitness Outcomes and Fundamental Motor Skills Among Youths [PDF]
, 2020 Antônio García‐Hermoso +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Journal of Rehabilitation, 2015 Objective: One of the most important issues in the development of fundamental motor skills in the early years of life is development of fine and gross motor skills.
Hassan Kordi
doaj