Results 121 to 130 of about 143,556 (259)

The Effect of Video Modeling on Gymnastics-Based Motor Skills in Children with Autism Spectrum Disorder. [PDF]

Healthcare (Basel)
Sönmez HG, Ergin M, Koçak ÇV, Bozdağ B, Kılınç Ö, Turan E, Canlı U, Aldhahi MI.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Associations Between Caregiver Smartphone Use in a Child's Presence and Motor Skills and Executive Function in Preschoolers: SUNRISE International Study. [PDF]

Child Care Health Dev
Toledo-Vargas M, Chong KH, Engberg E, Jáuregui A, Martins C, Byambaa A, López-Gil JF, Abdeta C, Mwase-Vuma T, El Hamdouchi A, Lubree H, Aoko OA, Chelly MS, Chia MYH, Ghofranipour F, Gonzalez-Santamaria J, Jarani J, Katewongsa P, Kontsevaya A, Singh P, Subedi N, Teo WP, Tiongco MM, Trampa K, Turab A, Užičanin E, Veldman SLC, Okely AD.   +27 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of a structured fundamental motor skills intervention on executive function in second grade students: a randomized controlled trial. [PDF]

Sci Rep
Chen C, Gao X, Cui X, Zhang W.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

From mannequins to humans - are manual therapy motor skills transferable? A mixed-methods study. [PDF]

BMC Med Educ
Funabashi M, Smith NM, Wong K, Gnjatic A, SmithBrudenell O, Starmer D, Howarth SJ, Choi G, Nim C.   +8 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effects of resistance training applied with a velocity-based approach on selected motor skills. [PDF]

BMC Sports Sci Med Rehabil
Gür S, Soyal M.
europepmc   +1 more source

Motor skills

Acta Psychologica, 1955
openaire   +1 more source